Principal Research Scientist I
About The Position
The Translational Safety Pharmacology department provides rigorous in vitro and in vivo safety assessments and fit-for-purpose assay development to support informed discovery and development decisions. The Principal Research Scientist serves as the in vivo cardiovascular safety pharmacology subject-matter leader, providing scientific and strategic leadership across rodent, canine, and nonhuman-primate models. The role leads the design, execution, interpretation, and reporting of cardiovascular safety studies; advances GLP and regulatory readiness; and collaborates across a matrixed organization to deliver reproducible, decision-ready data. The position also develops and implements fit-for-purpose cardiovascular assays, models, and SOPs; champions data quality and reproducibility; mentors scientists; communicates study strategy, results, and risk assessments to senior leadership and cross-functional and regulatory-facing teams; and helps advance cardiovascular safety pharmacology capabilities, workflows, and technologies. It manages team members directly and indirectly in a matrixed environment to plan, coordinate, and prioritize studies.
Requirements
- PhD in physiology, pharmacology, toxicology, or a related field.
- 10+ years of relevant experience in cardiovascular biology, safety pharmacology, or a closely related discipline.
- Demonstrated cardiovascular biology and safety pharmacology expertise, including the ability to design, execute, interpret, and report in vivo cardiovascular studies.
- Experience with rodent and large-animal studies, including canine and nonhuman-primate models.
- Experience authoring and implementing SOPs.
- Working knowledge of GLP, quality systems, and regulatory-ready documentation.
- Strong written and verbal scientific communication skills.
- Ability to lead in a matrixed environment, apply critical thinking, troubleshoot complex study issues, and manage multiple priorities effectively.
- At least one year of previous people management experience.
Responsibilities
- Lead the design, execution, quality, interpretation, and reporting of in vivo cardiovascular safety pharmacology studies across rodent, canine, and nonhuman-primate models.
- Provide scientific leadership for cardiovascular assessments, including hemodynamics, ECG and electrophysiology, pressure-volume loops, echocardiography, vascular reactivity, thrombosis, and relevant disease models.
- Develop, optimize, validate, and implement fit-for-purpose cardiovascular assays and models.
- Author and implement SOPs that support quality, consistency, and regulatory readiness.
- Champion data quality, reproducibility, and scientifically sound interpretation.
- Mentor scientists.
- Communicate study strategy, results, and risk assessments to senior leadership, cross-functional stakeholders, and regulatory-facing teams.
- Advance cardiovascular safety pharmacology capabilities, workflows, and technologies.
- Manage team members directly and indirectly in a matrixed environment to help plan, coordinate, and prioritize studies.
Benefits
- Paid time off, including vacation, holidays, and sick leave.
- Medical, dental, and vision insurance for eligible employees.
- 401(k) for eligible employees.
- Eligible to participate in long-term incentive programs.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
