Principal Research Scientist I, Checkpoint Immunology

AbbVie • Cambridge, MA

5d • $124,500 - $236,500

About The Position

The Checkpoint Immunology group is seeking an experienced Principal Research Scientist I to advance novel immune checkpoint programs for autoimmune and inflammatory diseases. The role provides scientific leadership across discovery and translational research, driving therapeutic concepts from target identification through candidate nomination. The scientist will lead biology in emerging areas where the path forward is not yet defined, remain closely involved in laboratory science, integrate work across functions, and help build a cohesive, collaborative team.

Requirements

• PhD with typically 6+ years of experience; MS or equivalent education with typically 12+ years of experience; or BS or equivalent education with typically 14+ years of extensive experience in Immunology, Cell Biology, Pharmacology, or a related discipline.
• Significant experience in immunology drug discovery and a demonstrated ability to innovate and deliver new or improved lead and candidate molecules.
• Experience with biologics, bispecific antibodies, multispecific therapeutics, or other immune-modulating modalities.
• Strong expertise in immune cell biology, autoimmune disease, immune regulation, and/or checkpoint biology.
• Demonstrated ability to independently lead scientific strategy and execution in a matrixed environment.
• Excellent communication, collaboration, and problem-solving skills.

Nice To Haves

• Experience advancing programs from target validation through candidate nomination.
• Experience designing and interpreting in vitro and in vivo pharmacology studies, including PK/PD assessments.
• Translational research and biomarker development experience.
• Proven ability to integrate cross-functional activities and drive execution across complex research programs.

Responsibilities

• Lead the scientific strategy and execution of one or more discovery-stage immunology programs.
• Drive biological understanding of novel immune regulatory pathways and translate insights into therapeutic opportunities.
• Design, execute, and interpret critical experiments while mentoring other scientists.
• Build scientific capability within the team and foster a strong drug discovery mindset.
• Integrate biology, pharmacology, translational sciences, and external collaborations to advance program objectives.
• Coordinate cross-functional workflows and drive alignment across multidisciplinary teams.
• Support high-quality project planning through sound experimental design, early risk assessment, robust contingency planning, and integrated timelines.
• Contribute to PK/PD, translational, and biomarker strategies that support candidate selection and development decisions.
• Foster a collaborative, high-performing team culture through mentorship, scientific rigor, and effective teamwork.

Benefits

• Paid time off, including vacation, holidays, and sick leave.
• Medical, dental, and vision insurance for eligible employees.
• 401(k) for eligible employees.
• Eligibility to participate in long-term incentive programs.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: Ph.D. or professional degree