Principal Mechanical Engineer II, Next-Gen Sequencing Systems, Research & Early Development

Roche•Santa Clara, CA

3d•$131,000 - $243,500•Onsite

About The Position

At Roche, we are working to make next-generation sequencing simple and accessible enough for routine use. By accelerating clinical research, streamlining workflows, and expanding assay menus, we are broadening access to genomic data and lowering barriers to adoption. From robust sample isolation and preparation tools to novel sequencing technology and advanced bioinformatics, we are developing differentiated, highly integrated end-to-end solutions for next-generation sequencing, resulting in a sample in, result out workflow. This hands-on role focusing on leading and solving mechanical challenges for our next-generation platforms. You will be responsible for conceptualizing, designing, building, and testing electro-mechanical, pneumatic, thermal, fluidic, and consumable solutions that ensure system performance, reliability, and longevity. As a technical authority, you will drive innovation and define solutions for novel DNA sequencing and automation challenges.

Requirements

A degree in Mechanical Engineering, or a closely related discipline, with relevant industry experience (minimum 10+ years for a Bachelor's, 7+ years for a Master's, or 6+ years for a PhD).
Demonstrated hands-on expertise designing, developing, and testing complex electro-mechanical, pneumatic, thermal, or fluidic assemblies, preferably for life science or diagnostic instrumentation.
A demonstrated level of expertise in SolidWorks for detailed design and the creation of manufacturing drawings.
A demonstrated level of expertise designing components for a variety of manufacturing processes (e.g., machining, sheet metal, injection molding, 3D printing).
Strong creative problem-solving skills; demonstrated ability to troubleshoot complex hardware, software, and chemistry interfaces.
A demonstrated level of proficiency with machine shop tools, measurement equipment, and rapid prototyping (e.g., CNC mills/lathes, laser cutters, 3D printers).
A demonstrated level of proactive experience and are naturally inquisitive, with a strong bias for action and a deep passion for developing next-generation life science instrumentation.
Strong interpersonal skills; ability to explain technical concepts to non-experts and thrive in ambiguous environments.
Excellent organizational skills with the ability to manage multiple projects efficiently.

Nice To Haves

Proficient with Python for device control and data acquisition.
Expertise with simulation tools (CFD, FEA) to guide design decisions.
Experience developing next-generation sequencing (NGS) or genomics instrumentation.

Responsibilities

Drive the research and development of various sub-systems, encompassing electro-mechanical, pneumatic, thermal, fluidic, and consumable technologies.
Collaborate with cross-functional teams to define and manage critical technical interfaces.
Own top level and/or sub-systems requirements, concepts, CAD, ordering, assembling through verification, integration, and troubleshooting, working closely with System Integration engineers.
Lead high-level cross-functional design reviews, acting as a technical authority to drive alignment, resolve complex trade-offs, and ensure the integrity of the overall system architecture.
Manage design deliverable timelines and contribute to overall project planning.
Create and maintain comprehensive design and test documentation including requirements, bill of materials, instrument schematics, tests plans, test reports, analyses, and presentations.
Contribute to technical strategy, providing data-driven recommendations on architecture and technology.
Present progress, data, and design trade-offs to stakeholders, clearly articulating the impact of engineering decisions.