Principal Investigator / LCMS Scientist

RPM ReSearch•Everett, WA

7d•Onsite

About The Position

RPM ReSearch has partnered with a leading preclinical Contract Research Organization (CRO) to identify a Principal Research Scientist – LC-MS/MS to join its growing bioanalytical sciences team. Our client partners with pharmaceutical and biotechnology companies to support the discovery and development of novel therapeutics through high-quality GLP bioanalytical services. This is an opportunity to join a collaborative scientific organization where your expertise will directly contribute to advancing new therapies toward the clinic. Important Qualification Experience supporting Antibody-Drug Conjugate (ADC) bioanalysis is required for this position. While we welcome applicants with strong LC-MS/MS backgrounds, this particular opportunity requires prior experience developing, validating, and/or supporting LC-MS/MS methods for ADCs within a GLP pharmaceutical or CRO environment. Candidates without ADC experience are unlikely to be a match for this role. As the Principal Research Scientist, you will serve as the technical and scientific expert for LC-MS/MS bioanalysis, with particular emphasis on ADCs and large molecule assays. You'll provide scientific leadership across method development, validation, sample analysis, study execution, and client interactions while collaborating closely with cross-functional scientific and regulatory teams in a GLP environment.

Requirements

Bachelor's, Master's, or Ph.D. in Chemistry, Biology, Immunology, or another relevant scientific discipline.
Significant hands-on experience with LC-MS/MS instrumentation and bioanalytical method development.
Demonstrated experience supporting Antibody-Drug Conjugate (ADC) bioanalysis.
Experience working within a GLP-regulated CRO or pharmaceutical environment.
Experience serving as a Principal Investigator, Senior Research Scientist, or comparable scientific leadership role.
Strong scientific writing, data interpretation, and client communication skills.
Ability to manage multiple studies while maintaining exceptional scientific quality and regulatory compliance.

Nice To Haves

Large molecule LC-MS/MS assays
Shimadzu and/or SCIEX instrumentation
Watson LIMS
FDA ICH M10 guidance
Bioanalytical method validation in support of drug development

Responsibilities

Provide scientific leadership for LC-MS/MS bioanalysis supporting both small and large molecule programs, including ADCs.
Lead method development, validation, troubleshooting, and sample analysis for GLP bioanalytical studies.
Serve as Principal Investigator or lead scientist on client-sponsored studies.
Partner directly with pharmaceutical and biotechnology clients, providing technical expertise and scientific consultation.
Prepare and review scientific reports, study documentation, and laboratory records.
Ensure compliance with GLP regulations, FDA guidance, SOPs, and quality standards.
Collaborate with Quality, Regulatory, and laboratory teams to support successful study execution and continuous process improvement.