Principal Associate Scientist, RNAi Discovery

Alnylam Pharmaceuticals•,

5d•$95,600 - $143,400•Onsite

About The Position

We are looking for a highly motivated Principal Associate Scientist to join our Research Analytics group and contribute to the further exploration of RNAi therapeutics. The successful candidate will help to support siRNA design and discovery through implementation of existing and novel analytical methods. Areas of focus include understanding in vivo/in vitro metabolism of siRNA in relevant tissue and cell types using established analytical methods, exploring stability of novel siRNA conjugates for targeted delivery, and developing robust analytical methods for early CMC work. This position is onsite and will be primarily located in Cambridge, MA.

Requirements

Bachelor’s or Master’s degree in Chemistry, Biochemistry, or a related field.
5-8 years of work experience, preferably in an industrial setting.
Ability to function within a highly interdisciplinary environment is a must.
Excellent written and oral communication skills, good organization skills, the ability to multitask, and the ability to work within a team and/or independently are required.
Strong commitment to high laboratory and scientific standards and the ability to maintain a safe, clean, and orderly laboratory work environment

Nice To Haves

Attention to detail with a commitment to accuracy and quality in experimental execution and design is highly preferred
Hands-on experience with ligand binding assays (e.g., hybridization ELISA, MSD, ELISA) is highly preferred.
Familiarity with bioanalytical techniques and instrumentation for PK analysis is preferred.
Experience with assay optimization, validation, and troubleshooting is preferred.
Familiarity with instrumentation such as HPLC, Gel Electrophoresis, etc. is preferred.

Responsibilities

Utilize analytical techniques such as hybridization ELISA, MSD, ELISA, HPLC, Gel Electrophoresis, and Western Blot to support pharmacokinetic and stability analysis of siRNA.
Effectively troubleshoot and optimize assay conditions and sample preparation protocols to improve assay sensitivity, specificity, and reproducibility.
Analyze and interpret ligand binding assay data to provide PK insights to present to team members.
Improve upon and/or develop new methods and automation for analysis of siRNA accumulation and stability.
Collaborate closely with cross-functional teams including PK/PD, bioanalytical, and discovery groups to integrate assay results.