Postdoctoral Researcher - Zhou lab

Buck Institute • Novato, CA

8d • Onsite

About The Position

The Buck Institute for Research on Aging is seeking a highly motivated Postdoctoral Researcher to investigate mitochondria–lysosome crosstalk in the context of aging and cellular senescence. This position will focus on understanding how communication between mitochondria and lysosomes regulates organelle function, cellular homeostasis, and age-associated decline. The successful candidate will use a combination of cell biology, advanced imaging, quantitative analysis, genetics, and mechanistic perturbation approaches to uncover how mitochondria–lysosome interactions contribute to organelle and cellular dysfunction associated with hallmarks of aging. The project will also explore new strategies to restore organelle communication and intervene in aging-associated phenotypes in the context of both normal aging and age-related diseases. The candidate will join a highly collaborative and multidisciplinary team that integrates biology, biophysics, imaging, quantitative analysis, computational biology, and artificial intelligence. This environment provides strong opportunities to combine experimental discovery with quantitative and computational approaches, particularly through high-content imaging, automated microscopy, and large-scale image analysis.

Requirements

• PhD in cell biology or related field
• Track record of first-author publications in related field
• Ability to work independently and collaboratively in a multidisciplinary research setting
• Strong verbal and written communication skills

Nice To Haves

• Passionate about uncovering basic principles of molecular and cellular biology.
• Excited to work at the interface of organelle biology, aging research, advanced imaging, and quantitative analysis.

Responsibilities

• Investigate mitochondria–lysosome crosstalk in the context of aging and cellular senescence.
• Understand how communication between mitochondria and lysosomes regulates organelle function, cellular homeostasis, and age-associated decline.
• Use cell biology, advanced imaging, quantitative analysis, genetics, and mechanistic perturbation approaches to uncover how mitochondria–lysosome interactions contribute to organelle and cellular dysfunction associated with hallmarks of aging.
• Explore new strategies to restore organelle communication and intervene in aging-associated phenotypes in the context of both normal aging and age-related diseases.
• Collaborate within a multidisciplinary team integrating biology, biophysics, imaging, quantitative analysis, computational biology, and artificial intelligence.

Benefits

• Medical/dental/vision coverage
• Paid time off
• Paid parental leave
• 401(k) employer contribution
• Student debt repayment option

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree