Postdoctoral Research Fellow (Grimes) - Immunobiology

Cincinnati Children's

4d

About The Position

The Grimes Lab at Cincinnati Children’s Hospital Medical Center is seeking a highly motivated Postdoctoral Fellow for a collaborative research program focused on hematopoiesis, response to infection, and molecular oncology. Led by H. Leighton “Lee” Grimes, PhD, the lab studies molecular and cellular mechanisms regulating normal and malignant hematopoiesis, with particular emphasis on myelopoiesis, bone marrow failure syndromes, myelodysplastic syndromes (MDS), severe congenital neutropenia (SCN), and acute myeloid leukemia (AML). The goal is to uncover biological and molecular mechanisms underlying these diseases and identify potential therapeutic opportunities.

The fellow may conduct research using mouse models of normal and malignant hematopoiesis; molecular and cellular studies of hematopoietic development and differentiation; single-cell RNA sequencing and other advanced single-cell technologies; transcriptional and epigenetic profiling; multi-omics approaches; investigation of MDS, SCN, AML, and other bone marrow disorders; and development and evaluation of small-molecule and RNA-based therapeutic approaches. The program integrates experimental biology with computational and bioinformatics approaches, including collaborative opportunities to analyze complex single-cell and multi-omics datasets.

The Grimes Lab has developed and applied approaches to hematopoietic biology, established mouse models of human diseases including AML and SCN, and contributed to research on hematopoietic differentiation, RNA splicing, epigenetic regulation, and disease-associated mutations. In collaboration with the Salomonis Lab, the team also develops biologically focused informatics tools and workflows for analyzing and visualizing single-cell data. Fellows work in a collaborative, multidisciplinary environment and can build expertise in experimental and computational research while contributing to research with potential therapeutic relevance.

The position provides training in wet-bench and computational approaches, advanced single-cell and multi-omics technologies, collaborative and translational research, scientific presentation and publication, scientific writing and communication, and independent research skills. The fellow will progressively develop the critical thinking, data analysis, specific-aim development, project planning, and experimental-design skills needed for an independent research career. Responsibilities also include experiment design and execution, data analysis, method improvement and troubleshooting, communication of findings, scientific writing, mentoring research staff, fiscal administration, continuing education, and compliance with institutional policies and required training.

Requirements

• PhD, MD, MD/PhD, or equivalent doctoral degree in a relevant scientific discipline; the required qualifications also state PhD/MD or equivalent.
• Strong background in molecular biology, cell biology, hematology, cancer biology, immunology, genetics, genomics, bioinformatics, or a related field.
• Demonstrated interest in hematopoiesis, leukemia, bone marrow disorders, molecular oncology, or related areas.
• Strong analytical, problem-solving, and scientific communication skills.
• Ability to work independently and collaboratively in a multidisciplinary research environment.

Nice To Haves

• Experience with mouse models, molecular biology techniques, single-cell sequencing, genomics, epigenetics, computational biology, or bioinformatics is desirable.

Responsibilities

• Develop critical thinking, data-analysis, specific-aim development, long-term project-planning, and experimental-design skills to become an independent scientist.
• Design, execute, and record laboratory experiments and analyze data that may affect decisions regarding future patient care.
• Research and improve current methods and evaluate innovative techniques; conduct regular quality and reproducibility checks on protocols and assays; implement findings in the division or department; and troubleshoot erroneous results or laboratory-equipment problems.
• Discuss experimental insights with faculty and provide recommendations and analysis.
• Present research at laboratory meetings, journal clubs, seminars, and meetings; critically review and discuss presented data.
• Draft, write, and edit scientific reports, papers, journal articles, abstracts, and grants.
• Assume progressively increasing responsibilities, including mentorship of research staff and fiscal administration.
• Maintain current knowledge through continuing education, literature, and seminars; participate in intellectual discussions with the PI, faculty, trainees, and research staff; and seek career feedback from the PI, mentoring committee, and others.
• Attend required Cincinnati Children’s training sessions and comply with institutional policies and procedures, including applicable Infection Control and ORCRA requirements.
• Perform other duties as assigned.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree