Postdoctoral Research Fellow

Mass General Brigham • Boston, MA

2d • $70,000 - $71,750 • Onsite

About The Position

The Miller Laboratory at the Massachusetts General Hospital Center for Systems Biology is recruiting a full-time Postdoctoral Research Fellow. The Miller Laboratory for Precision Therapeutics develops new chemical and nanotechnology-based approaches for spatially controlled cancer therapy. Our research combines organic synthesis, bioconjugate chemistry, drug delivery, molecular imaging, cancer biology, immunology, and quantitative tissue analysis to understand and engineer how therapeutics behave within tumors.

The successful candidate will lead projects involving radiation-activated chemistry, drug conjugates, and externally triggered therapeutic systems. Research may include the design and organic synthesis of radiation-responsive linkers and prodrugs; development of antibody, protein, polymer, or nanoparticle conjugates; investigation of radiation-mediated payload activation; and characterization of new compounds using HPLC, LC–MS, NMR spectroscopy, and related analytical methods.

Projects may also incorporate radiopharmaceuticals, ultrasound-responsive drug delivery, bioorthogonal chemistry, molecular imaging, and studies of the tumor immune microenvironment. Therapeutic distribution and response may be evaluated using preclinical tumor models, multiplex tissue imaging, flow cytometry, single-cell analysis, and spatial-omics techniques.

The fellow will work within a multidisciplinary environment and collaborate with chemists, cancer biologists, immunologists, engineers, imaging scientists, radiation oncologists, and other physician-scientists across Massachusetts General Hospital and the broader Harvard research community.

Requirements

• PhD or equivalent doctoral degree in organic chemistry, chemical biology, biological chemistry, medicinal chemistry, materials chemistry, bioengineering, or a related discipline.
• Strong hands-on experience in organic synthesis and/or bioconjugate chemistry.
• Experience in at least one additional relevant area, such as nanoparticle formulation, polymer chemistry, medicinal chemistry, biomaterials, or drug delivery.
• Ability to work effectively both independently and as part of a multidisciplinary research team.
• Candidates who expect to complete their doctoral degree before the anticipated start date are encouraged to apply.

Nice To Haves

• Antibody–drug, protein–drug, or polymer–drug conjugates.
• Stimuli-responsive or activatable chemistry.
• Nanoparticle formulation and physicochemical characterization.
• Radiochemistry and radiopharmaceuticals.
• Cancer biology, tumor models, or cancer immunology.
• Molecular imaging and microscopy.
• Ultrasound-responsive materials or drug-delivery systems.
• Pharmacology, pharmacokinetics, or biodistribution.
• Flow cytometry, multiplex tissue imaging, single-cell sequencing, or spatial omics.
• Strong chemistry backgrounds who are interested in expanding into cancer biology, imaging, immunology, and translational therapeutics.

Responsibilities

• Lead projects involving radiation-activated chemistry, drug conjugates, and externally triggered therapeutic systems.
• Design and organic synthesis of radiation-responsive linkers and prodrugs.
• Development of antibody, protein, polymer, or nanoparticle conjugates.
• Investigation of radiation-mediated payload activation.
• Characterization of new compounds using HPLC, LC–MS, NMR spectroscopy, and related analytical methods.
• Incorporate radiopharmaceuticals, ultrasound-responsive drug delivery, bioorthogonal chemistry, molecular imaging, and studies of the tumor immune microenvironment into projects.
• Evaluate therapeutic distribution and response using preclinical tumor models, multiplex tissue imaging, flow cytometry, single-cell analysis, and spatial-omics techniques.
• Work within a multidisciplinary environment and collaborate with chemists, cancer biologists, immunologists, engineers, imaging scientists, radiation oncologists, and other physician-scientists.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree