Postdoctoral Research Fellow, Anesthesiology

American Addiction Centers • Winston-Salem, NC

1d • Onsite

About The Position

This Postdoctoral Fellow position is essential for the successful execution of a highly technical, multi aim translational research project focused on uncovering immune mechanisms underlying chemotherapy induced peripheral neuropathy (CIPN) in the context of breast cancer treatment. The proposed research integrates complex orthotopic tumor models, immune specific genetic manipulations, advanced neurobehavioral phenotyping, and translational pharmacologic interventions, all of which require a dedicated, full time postdoctoral scientist with advanced methodological and analytical expertise.

Requirements

• Advanced methodological and analytical expertise.
• Full-time dedication to the research project.

Responsibilities

• Lead and coordinate immunocompetent, orthotopic breast cancer resection models combined with adjuvant chemotherapy.
• Execute complex longitudinal CIPN behavioral assays (mechanical allodynia, cold sensitivity).
• Perform immune specific genetic and pharmacologic manipulations targeting the IRE1α XBP1 pathway.
• Conduct advanced flow cytometry, FACS sorting, molecular assays (qPCR, ELISA), histology, and confocal imaging.
• Integrate tumor progression endpoints (recurrence, lung metastases, IVIS imaging) with neurotoxicity and immune outcomes.
• Perform ex vivo co culture assays linking immune cell activation to neuronal injury and tumor aggressiveness.
• Evaluate translational pharmacologic strategies (MKC 8866 ± paclitaxel) across multiple disease contexts.
• Analyze high dimensional data across behavioral, molecular, immune, and oncologic endpoints.
• Prepare manuscripts, conference presentations, and progress reports for funding agencies.
• Contribute to grant development supporting continuation and expansion of the research program.
• Provide day to day mentorship to trainees (graduate students and research staff) in specialized techniques.
• Foster cross disciplinary collaboration between cancer biology, immunology, neuroscience, and anesthesiology.

Benefits

• Paid Time Off programs
• medical, dental, vision, life, and Short- and Long-Term Disability
• Flexible Spending Accounts for eligible health care and dependent care expenses
• adoption assistance and paid parental leave
• Defined contribution retirement plans with employer match and other financial wellness programs
• Educational Assistance Program

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree