Postdoctoral Fellow-MSH-30025-251
About The Position
The research aims to uncover the molecular mechanisms that govern cancer cell behavior by focusing on functional heterogeneity within tumors, phenotypic plasticity during tumor evolution and therapy response, and cellular competence in tumor initiation, adaptation, and drug resistance. Rather than simply cataloging cellular states, the goal is to identify the mechanisms that establish, maintain, and regulate them. This is achieved by combining genetic barcoding-based lineage tracing, functional genomics, organoid and mouse models, CRISPR perturbations, and single-cell multiomics to track cancer evolution at clonal resolution and uncover causal regulators of cancer cell identity and behavior. The laboratory fosters a collaborative and interdisciplinary approach with both experimental and computational researchers studying cancer evolution and cell-state dynamics. Current research areas include cellular competence and tumor evolution, phenotypic plasticity, memory, and adaptation, and developmental programs and cancer cell states.
Requirements
- PhD or equivalent degree in a relevant scientific field.
- Experience in cancer research.
- Proficiency in genetic barcoding-based lineage tracing.
- Experience with functional genomics.
- Experience with organoid and mouse models.
- Experience with CRISPR perturbations.
- Experience with single-cell multiomics.
- Ability to track cancer evolution at clonal resolution.
- Ability to uncover causal regulators of cancer cell identity and behavior.
- Strong collaborative and interdisciplinary research skills.
- Commitment to fostering an environment of fairness and continuous learning.
Responsibilities
- Conduct research to uncover molecular mechanisms governing cancer cell behavior.
- Focus on functional heterogeneity within tumors.
- Investigate phenotypic plasticity during tumor evolution and therapy response.
- Study cellular competence in tumor initiation, adaptation, and drug resistance.
- Identify mechanisms that establish, maintain, and regulate cellular states.
- Utilize genetic barcoding-based lineage tracing.
- Employ functional genomics.
- Work with organoid and mouse models.
- Perform CRISPR perturbations.
- Conduct single-cell multiomics.
- Track cancer evolution at clonal resolution.
- Uncover causal regulators of cancer cell identity and behavior.
- Collaborate with experimental and computational researchers.
- Contribute to a culture of excellence, fairness, and continuous learning.
Benefits
- Access to a leading school of medicine and graduate education.
- Opportunities for professional development.
- Supportive and welcoming environment.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree
