Postdoctoral Fellow-MSH-30025-251
About The Position
Our research aims to uncover the molecular mechanisms that govern cancer cell behavior by focusing on functional heterogeneity within tumors, phenotypic plasticity during tumor evolution and therapy response, and cellular competence in tumor initiation, adaptation, and drug resistance. Rather than simply cataloging cellular states, we seek to identify the mechanisms that establish, maintain, and regulate them. We combine genetic barcoding-based lineage tracing, functional genomics, organoid and mouse models, CRISPR perturbations, and single-cell multiomics to track cancer evolution at clonal resolution and uncover causal regulators of cancer cell identity and behavior. The laboratory includes both experimental and computational researchers, fostering a collaborative and interdisciplinary approach to studying cancer evolution and cell-state dynamics. Current Research Areas include Cellular competence and tumor evolution, Phenotypic plasticity, memory, and adaptation, and Developmental programs and cancer cell states. Join an NIH-funded laboratory and help shape an ambitious research program at the intersection of cancer biology, epigenetics, stem cell biology, and genomics. Trainees will receive close mentorship, access to state-of-the-art technologies, and strong support for career development and scientific independence.
Requirements
- Ph.D. in Cancer Biology, Molecular Biology, Genetics, Epigenetics, Stem Cell Biology, or a related field.
- Strong publication record or evidence of research productivity.
- Ability to work independently and collaboratively.
- Experience with molecular biology and mammalian cell culture.
Nice To Haves
- Organoids or mouse models
- Genetic barcoding, clonal tracking, and lineage tracing
- Single-cell genomics and multiomics
- ATAC-seq, RNA-seq, CUT&Tag, or CUT&RUN
- CRISPR technologies
Responsibilities
- Design and execute independent research projects.
- Perform experiments using organoid, cell culture, and mouse models.
- Conduct genetic barcoding, lineage tracing, and functional genomics studies.
- Contribute to manuscripts, grant applications, and mentoring activities.
Benefits
- Close mentorship
- Access to state-of-the-art technologies
- Strong support for career development and scientific independence
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree
