Postdoctoral Fellow-MSH-30001-336
About The Position
The Alison Goate laboratory in the Departments of Genetics and Genomic Sciences and of Neuroscience at the Icahn School of Medicine at Mount Sinai in New York City is currently looking for highly skilled and motivated molecular and cell biologists to be the drivers of our efforts to translate the human genetics of Alzheimer’s disease (AD) into effective preventative and therapeutic interventions. Core areas of focus will be translating genetics and human biology observations into both in vitro (induced pluripotent stem cell models) and in vivo systems (mouse models) to understand innate immune modifiers of AD pathogenesis. In particular, the Goate lab concentrates on identifying human genetic variants associated with AD and dissecting the molecular, cellular, and tissue-level mechanisms by which these variants and the associated genes (e.g., APOE, TREM2, SPI1/PU.1, MEF2C, MS4A) modulate disease risk, with a major focus on the role of microglial cell function (e.g., phagocytic clearance of cholesterol-rich cellular debris) in the maintenance of brain tissue homeostasis during aging and in disease conditions. In vivo studies are being performed to study the impact of risk genes on AD pathology and to test novel therapeutic approaches. In addition, the Goate lab also investigates how the human genetics of the 17q21.31 “MAPT/tau” locus contributes to mechanisms underlying Tauopathy, and translating this work into effective preventative and therapeutic interventions. Core areas of focus will be translating genetics and human biology observations into in vitro (induced pluripotent stem cell models) models to understand the role of 17q21.31 on disease pathogenesis. The candidate will join a multidisciplinary and highly collaborative research team that includes geneticists, computational biologists, immunologists, neuroscientists, and physician-scientists at the Ronald M. Loeb Center for Alzheimer’s Disease, as well as at other leading US and European academic institutions and biopharmaceutical companies.
Requirements
- Highly skilled and motivated molecular and cell biologists.
- Experience with induced pluripotent stem cell models.
- Experience with mouse models.
Nice To Haves
- Experience in genetics and human biology.
- Experience with innate immune modifiers of AD pathogenesis.
- Experience with APOE, TREM2, SPI1/PU.1, MEF2C, MS4A genes.
- Experience with microglial cell function.
- Experience with phagocytic clearance of cholesterol-rich cellular debris.
- Experience with Tauopathy.
- Experience working in a multidisciplinary and highly collaborative research team.
- Experience working with geneticists, computational biologists, immunologists, neuroscientists, and physician-scientists.
Responsibilities
- Translate human genetics of Alzheimer’s disease (AD) into effective preventative and therapeutic interventions.
- Translate genetics and human biology observations into in vitro (induced pluripotent stem cell models) and in vivo systems (mouse models) to understand innate immune modifiers of AD pathogenesis.
- Identify human genetic variants associated with AD and dissect the molecular, cellular, and tissue-level mechanisms by which these variants and associated genes modulate disease risk.
- Investigate the role of microglial cell function in the maintenance of brain tissue homeostasis during aging and in disease conditions.
- Perform in vivo studies to investigate the impact of risk genes on AD pathology and test novel therapeutic approaches.
- Investigate how the human genetics of the 17q21.31 “MAPT/tau” locus contributes to mechanisms underlying Tauopathy.
- Translate work on the 17q21.31 locus into effective preventative and therapeutic interventions.
- Translate genetics and human biology observations into in vitro (induced pluripotent stem cell models) models to understand the role of 17q21.31 on disease pathogenesis.
Benefits
- NIH funded
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree
