Postdoctoral Fellow (Lin Lab)
About The Position
Postdoctoral positions are available in the Lin lab to investigate the role of cardiomyocyte innate immune responses in heart diseases. Cardiomyocytes (CMs) are the building blocks and functional units of the heart, and their dysfunction or loss is the root of heart failure. Similar to other specialized innate immune cells, CMs possess their own innate immune molecular machinery. Ischemic or non-ischemic pathological stress activates CM innate immune signaling pathways, which stimulate pro-inflammatory cytokine release and reactive oxygen species (ROS) production. While these innate immune responses are beneficial for defending CMs against pathogen invasion and for tissue repair, they can also cause myocardial damage. The Lin lab's long-term goal is to define novel molecular mechanisms that regulate CM innate immune responses, which will shed light on the pathogenesis of pathogen or non-pathogen related cardiomyopathy. To achieve this goal, the lab performs tissue-specific gene gain- and loss-of-function studies to analyze the pathophysiological roles of the Hippo-YAP pathway in the heart. They also utilize Adeno-associated-virus (AAV) and modified messenger RNA as gene delivery platforms for translational studies, aiming to develop drug candidates for treating cardiovascular diseases.
Requirements
- Molecular biology or cell biology background.
- Highly motivated, career driven, independent, team working, and reliable.
- Willingness to work with mice and manage mouse colonies.
Nice To Haves
- Hands-on experience working with animals.
Responsibilities
- Investigate the role of cardiomyocyte innate immune responses in heart diseases.
- Perform tissue-specific gene gain- and loss-of-function studies.
- Analyze the pathophysiological roles of the Hippo-YAP pathway in the heart.
- Utilize Adeno-associated-virus (AAV) and modified messenger RNA as gene delivery platforms for translational studies.
- Work with mice and manage mouse colonies.
Benefits
- Excellent benefit package.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
No Education Listed
