Postdoctoral Fellow-MSH-32076-169
About The Position
The Brody Laboratory is seeking highly motivated postdocs to lead projects aimed at Improving the Anti-Tumor Immune Response Induced by in situ vaccination. The current phase of this longstanding Project is to potentiate tumoral recruitment of professional Antigen Presenting Cells, particularly type 1 Dendritic Cells (DC1) and assess the impacts on presentation and cross-presentation of surrogate and neo-epitope tumor antigens to tumor-reactive T cells as well as their subsequent priming and induction of systemic anti-tumor immune response. Recent advances in the development and understanding of mRNA-lipid nanoparticles has facilitated our preliminary data showing that specific DC-recruiting chemokines can be mRNA-encoded and produced by tumors in vitro and in vivo to increase DC1-migration.
Requirements
- Ph.D. required
- Experience working in a research laboratory setting
Responsibilities
- Perform independent research in the area of cancer immunotherapy and molecular biology.
- Develop in silico, in vitro, and in vivo data and models to assess the impact of chemokine-mRNA-LNP therapy on DC1 recruitment and induction of in situ vaccinal anti-tumor effects.
- Critically analyze data quality and results.
- Communicate results to scientists and lay people.
- Write or assist in writing scientific papers and grants.
- Collaborate closely with other scientists to conduct research.
Benefits
- According to UAW/Mount Sinai agreement
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
