Post-Doctoral Fellow

University of Colorado • Aurora, CO

1d • $63,480 - $64,380 • Onsite

About The Position

The Van Rechem Lab is seeking a highly motivated postdoctoral fellow to join our team. Our long-term research interest is to understand how chromatin modifiers contribute to disease development and progression in order to uncover more effective therapeutic opportunities. We focus particularly on brain cancers, including pediatric diffuse midline glioma (DMG) and rhabdoid tumors, and investigate how epigenetic dysregulation drives tumor biology. Our laboratory investigates the direct molecular impact of chromatin modifiers during cell cycle progression and explores both canonical nuclear functions and unappreciated cytoplasmic roles, including the regulation of translation. We aim to define how chromatin state influences replication dynamics, genome stability, and cellular fitness in both normal and pathological contexts. By integrating mechanistic chromatin biology with disease-focused models of brain cancer, we seek to identify new biomarkers and targeted therapeutic strategies.

Requirements

• Graduation from an accredited college or university with a PhD/MD in one of these fields of Neuroscience, Biology, or a related field
• Strong quantitative and analytical skills, including experience with genomics data analysis (R, Python, or related tools)
• Excellent written and verbal communication skills, including manuscript and grant preparation
• Proven ability to develop and lead independent research projects
• Ability to work both independently and collaboratively within interdisciplinary teams
• Strong organizational skills and attention to experimental rigor and reproducibility

Nice To Haves

• Experience with chromatin profiling approaches (e.g., ChIP-seq, CUT&RUN, CUT&Tag) and/or replication timing or R-loop mapping assays
• Background in chromatin biology, cancer biology, DNA replication, genome instability, or translational control
• Experience with next-generation sequencing–based methods and multi-omics data integration
• Proficiency in genome engineering techniques (e.g., CRISPR/Cas systems)
• Experience working with cancer models, particularly brain cancer systems

Responsibilities

• Lead an independent research project aligned with the laboratory’s focus on chromatin regulation and brain cancer biology.
• Developing mechanistic hypotheses, designing and executing experiments using molecular, genomic, and cell-cycle–resolved approaches, integrating multi-omics datasets, and driving the project from conception to publication.
• Analyze and interpret complex datasets, prepare manuscripts, present findings at national and international conferences.
• Investigates the direct molecular impact of chromatin modifiers during cell cycle progression and explores both canonical nuclear functions and unappreciated cytoplasmic roles, including the regulation of translation
• Apply for competitive fellowships and career development awards

Benefits

• Competitive salary
• Generous leave
• Health plans
• Retirement contributions

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree