The laboratory delves into the intricate mechanisms governing basal and pathological bone turnover at the Immuno-skeletal Interface. This field, known as “osteoimmunology,” explores the paradoxical role of immune cells and cytokines in driving skeletal metabolism. Our research encompasses the targeting of anergic T cells to stimulate bone formation and the utilization of costimulation inhibitors targeting CD8 T cells to enhance skeletal regeneration. Additionally, we investigate the mechanisms and functions of the microbiota underlying skeletal damage associated with HIV immunodeficiency. This includes HIV-antiretroviral therapy-induced immune reconstitution bone loss (IRBL), a severe side effect of antiretroviral drugs that severely damages the skeleton. The laboratory is currently supported by grants from both the National Institutes of Health (NIH) and the Department of Veterans Affairs (VA). The ideal applicant should possess US citizenship and a robust background in one or more of the following specialized areas:1. Comprehensive knowledge of osteoimmunology and/or bone biology.2. Expertise in fundamental skeletal phenotyping technologies, including micro-CT and quantitative bone histomorphometry.3. Proficiency in flow cytometry.4. Strong skills in mouse husbandry are essential, with additional proficiency in minor surgical procedures such as ovariectomy highly desirable.5. Familiarity with fundamental molecular and protein biochemistry techniques is advantageous. JOB DESCRIPTION: Helps design and conduct research within a specified field while receiving advanced training from a designated Principal Investigator to enhance professional skills and research independence needed for pursuit of a career. The specific area of research in which the trainee is mentored is determined by the department and laboratory of the Postdoc. Designs and evaluates experiments. Develops new ideas that promote current research. Prepares and publishes scientific manuscripts under the direction of the Principal Investigator. May be responsible for operation o f specific equipment. May teach techniques to others, train, and supervise research staff. Positions are temporary appointments as a research trainee. The initial appointment is for one year, renewal expected if progress is satisfactory and funds are available. Appointments cannot exceed five years.
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Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree