Postdoctoral Fellow/ Scientist I, T Cell Biology and Tissue Immunology
About The Position
The Parsa Lab (Immune Cell Dynamics and Function group) at Biohub New York is seeking a highly motivated Postdoctoral Fellow or Scientist I to investigate how T cells interact with local tissue environments and how these interactions shape immune responses in health and disease. The research focuses on cellular and molecular mechanisms governing T cell differentiation, function, and adaptation across tissues, particularly how immune cells and their surrounding microenvironments shape responses in inflammatory settings. The long-term goal is to develop strategies for reprogramming immune cells in disease- and tissue-specific ways for therapeutic benefit. The successful candidate will develop innovative research projects to understand how immune cells interact with tissue microenvironments and establish persistent cellular networks that shape tissue homeostasis, function, and responses to subsequent challenges. Research combines experimental immunology with genetically engineered mouse models, single-cell genomics, spatial transcriptomics, genetic perturbation, and machine learning or artificial intelligence. The role is part of a collaborative environment spanning immunology, genomics, computational biology, and technology development. The lab seeks a creative and independent scientist with a strong experimental biology, genetic engineering, bioengineering, or functional genomics background and interest in scalable in vivo approaches to complex biological systems. The position offers opportunities to develop experimental technologies, contribute to multidisciplinary research, and establish an independent scientific direction.
Requirements
- PhD in molecular biology, bioengineering, genetics, cell biology, immunology, or a related field.
- At least 3 years of experience with demonstrated impact in experimental molecular and cellular biology.
- For the Scientist position, at least 2 years of post-PhD experience.
- Demonstrated experience with mouse models and tissue processing.
- Hands-on experience with molecular cloning, genetic engineering, or genetic perturbation approaches.
- Experience designing, optimizing, and troubleshooting complex experimental workflows.
- Ability to independently design, execute, and interpret experiments.
- Strong scientific curiosity, creativity, and problem-solving skills.
- Excellent communication and collaboration skills.
- Interest in applying engineering and functional genomics approaches to understand complex biological systems.
Nice To Haves
- Experience with scalable genetic perturbation approaches, including pooled CRISPR screens, in vivo perturbation strategies, or functional genomics.
- Experience studying immune cell differentiation, activation, migration, or effector function.
- Experience with mouse disease models.
- Experience with single-cell RNA sequencing, spatial transcriptomics, or other high-dimensional genomic technologies.
- Experience with molecular cloning, viral vector engineering, or genetic manipulation of mammalian cells.
- Experience with advanced flow cytometry, cell sorting, or imaging techniques.
- Experience analyzing high-dimensional immunological datasets.
Responsibilities
- Investigate cellular and molecular mechanisms regulating immune cell responses and interactions within tissue microenvironments.
- Design and perform in vivo experiments using mouse models.
- Characterize immune cell differentiation, function, and interactions with other cells.
- Apply experimental approaches including molecular biology, single-cell sequencing, spatial transcriptomics, and genetic perturbation technologies.
- Develop and test hypotheses about how immune cells and local tissue environments reciprocally shape each other’s behavior and function.
- Collaborate with experimental and computational scientists across Biohub to integrate cellular, molecular, and spatial datasets.
- Independently design, execute, and analyze experiments.
- Present scientific findings at meetings and conferences and prepare manuscripts for publication.
- Contribute to the scientific development of the laboratory and mentor junior researchers.
Benefits
- Employer match on employee 401(k) contributions.
- Paid time off to volunteer at an organization of the employee’s choice.
- Funding for select family-forming benefits.
- Relocation support for employees who need assistance moving.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
