Postdoctoral Fellow, High Throughput Purification Process Development

Roche • South San Francisco, CA

6d • Onsite

About The Position

Genentech’s Pharma Technical Development Purification Robotics & Modeling group is seeking a postdoctoral fellow to investigate, implement, and optimize high throughput miniaturized screening platforms to accelerate purification process development. This postdoctoral project aims to significantly enhance development efficiency and reduce cycle time by developing high-throughput, low-mass screening techniques for assessing resin binding of hundreds of therapeutic products at a time. This project will explore and validate miniaturized approaches to characterize interactions between chromatography resins, candidate molecules, and their variants, enabling earlier assessment and rapid generation of process information. This early assessment will enable stronger connections between molecular design and process development, where the postdoctoral fellow can help support optimal design of candidate molecules with reduced manufacturability risks. The postdoctoral fellow will have the opportunity to collaborate with experts across the organization in automation, process development, analytics, modeling, and research, opening new areas of investigation when the opportunity arises. The broad exposure the candidate will experience will help to define and guide their career path.

Requirements

• Ph.D in Chemical Engineering, Bioengineering, Chemistry, Biochemistry or related engineering or science discipline
• Strong work ethic, must be self-motivated, flexible, able to multitask, and meet timelines efficiently and productively
• Excellent written and verbal communication and interpersonal skills, with a demonstrated ability to collaborate effectively with multidisciplinary teams
• Strong use of critical thinking to design, analyze, and troubleshoot experiments
• Ability to translate scientific literature in practical solutions

Nice To Haves

• Knowledge of protein purification principles, analytical techniques, and high throughput screening techniques
• Hands-on experience with laboratory automation and robotic systems, such as liquid handlers (e.g. TECAN, Hamilton)
• Experience with protein binding assays a plus
• Experience with computational modeling of physical or chemical processes a plus
• Proficiency in Python, VB, VBA, and/or R a plus

Responsibilities

• Investigate, implement, and optimize high throughput miniaturized screening platforms to accelerate purification process development.
• Develop high-throughput, low-mass screening techniques for assessing resin binding of hundreds of therapeutic products at a time.
• Explore and validate miniaturized approaches to characterize interactions between chromatography resins, candidate molecules, and their variants.
• Enable earlier assessment and rapid generation of process information.
• Support optimal design of candidate molecules with reduced manufacturability risks.
• Collaborate with experts across the organization in automation, process development, analytics, modeling, and research.
• Open new areas of investigation when the opportunity arises.

Benefits

• Relocation benefits are available for this job posting.
• Competitive salaries
• Fully funded research expenses
• Mentorship and support necessary to develop into an independent scientist and leader
• Access to world-class seminars, professional development workshops, and networking opportunities

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree