Postdoctoral Associate

Duke Careers • Durham, NC

3d • Onsite

About The Position

The Boyce Laboratory in the Department of Biochemistry at Duke University seeks a talented, motivated, and collegial postdoctoral fellow to join a newly funded NINDS R01 project investigating how O-GlcNAc glycosylation regulates KLHL-family E3 ubiquitin ligases (gigaxonin, KLHL3) and their substrates (neurofilaments, WNK kinases) in neuronal proteostasis, cytoskeletal dynamics, and ferroptotic cell death. This collaborative work combines biochemistry, chemical biology, cell signaling, live-cell imaging, and organotypic brain slice models to dissect the mechanistic links between intracellular glycosylation and neurodegeneration. By mutual agreement with the PI, the exact portfolio within the larger project may be adjusted to suit the postdoc’s background, interests, and professional goals. The successful candidate will have access to a rigorous, well-funded, inclusive, and highly collaborative research environment with state-of-the-art core facilities and opportunities to develop independent expertise across multiple experimental systems, from cell lines to primary neurons to ex vivo brain tissue. The postdoc will be encouraged to develop a unique scientific identity within the broader project, lead publications, present their work at national conferences, mentor junior researchers, and develop the skills and preliminary data needed for an independent research career in any sector.

Requirements

• Ph.D. or equivalent doctoral training in biochemistry, cell biology, neuroscience, or a related field.
• Intellectually curious.
• Works well independently and as part of a team.
• Committed to rigorous, reproducible science.

Nice To Haves

• Research experience in cellular neurobiology and/or O-GlcNAc signaling or glycobiology more broadly.
• Strong backgrounds in adjacent areas and a firm commitment to learning glycobiology approaches.

Responsibilities

• Investigate how O-GlcNAc glycosylation regulates KLHL-family E3 ubiquitin ligases and their substrates in neuronal proteostasis, cytoskeletal dynamics, and ferroptotic cell death.
• Combine biochemistry, chemical biology, cell signaling, live-cell imaging, and organotypic brain slice models to dissect mechanistic links between intracellular glycosylation and neurodegeneration.
• Develop a unique scientific identity within the broader project.
• Lead publications.
• Present work at national conferences.
• Mentor junior researchers.
• Develop skills and preliminary data needed for an independent research career.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree