POSTDOCTORAL ASSOCIATE - Cell Biology & Chemical Biology - Calibr-Skaggs

Scripps Research • San Diego, CA

6d • Onsite

About The Position

Calibr-Skaggs, a division of Scripps Research, is seeking a Postdoctoral Associate to join an early-stage discovery research group. The candidate will perform research in biochemistry and protein engineering, focusing on discovering, characterizing, and optimizing toxin-neutralizing antibodies and monobodies for human therapeutic use. The role involves engagement throughout the drug discovery pipeline, from early discovery to IND. A successful candidate will be self-led, capable of independent and collaborative work, and adaptable with a willingness to learn new skills and techniques. The institute is dedicated to creating the next generation of medicines by pairing world-class biomedical research with drug discovery and development capabilities.

Requirements

• PhD in biochemistry, chemical biology, or related area, or an equivalent combination of education and training.
• Strong track record of research productivity.
• Highly motivated, creative, and devoted to project goals.
• Able to collaborate proficiently and communicate effectively with colleagues and management teams.
• Able to contribute in a meaningful way to scientific discourse.
• Core knowledge of protein engineering (expression, purification, characterization).
• Experience with plasmid cloning.
• Experience with western blots and/or ELISA.
• Experience with FRET assays.
• Experience with mammalian cell culture and cell transfection (HEK293).
• Experience with HPLC and LC-MS.
• Experience in drug discovery and an understanding of protein-protein interactions.

Nice To Haves

• Experience with directed evolution techniques is a plus.
• Prior work with animal models.
• Prior work with directed evolution strategies.
• Prior work with primary mammalian cells.

Responsibilities

• Work within discovery project teams and with scientists across different functional areas.
• Present work at project team meetings and to research leadership.
• Design, execute, analyze, interpret, and troubleshoot scientific experiments in molecular biology and biochemistry independently.
• Maintain accurate written reports and present results in an organized and timely manner.
• Communicate effectively with peers and supervisors, foster teamwork, and contribute to collaborative efforts.
• Develop and implement robust bacterial protein expression and purification workflows.
• Characterize biochemical and biophysical properties of candidate antibody/monobody therapeutics.
• Establish biochemical and cell-based enzymatic activity and protein-protein interaction assays.

Benefits

• Eligibility for retirement plans with employer contribution.
• Full suite of Health and Welfare plans including four medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more.
• Access to Dependent Flexible Spending Accounts.
• Paid Time Off - 5 days annually.
• Free, on-site Counseling Center which provides confidential counseling services to benefits-eligible employees.
• Free, on-site parking.
• Pet Insurance.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree