Postdoctoral Associate - GaMBiT Initiative

Broad Institute • Cambridge, MA

6d • $70,000 - $92,667 • Onsite

About The Position

The Klarman Fellowship is a postdoctoral research program within the Broad Institute of MIT and Harvard’s GaMBiT Initiative. The initiative works to bridge the gap between genetic discoveries and therapeutic interventions by scaling experiments that clarify disease mechanisms, identifying biomarkers to measure those mechanisms, building computational frameworks that connect human genetics data with experiments, and developing therapeutic approaches to remediate discovered mechanisms.

The fellowship welcomes computational and experimental researchers interested in developing and applying technologies relevant to the GaMBiT mission. Research may involve areas such as statistical and computational genetics, cellular and organismal biology, immunology, metabolomics, proteomics, protein structure, and chemistry. Roles may include large-scale analyses across biobanks, integration of study data into disease genome maps, tools that help experimentalists access disease-specific genomic information, AI agents that interpret genetic data using biological knowledge from literature, scalable editing of human cell types, single-cell profiling of proteins and other molecular features, and development of human genetics-derived cellular models and patient-tissue organoids.

Postdoctoral associates will be based at the Broad Institute and work with a mentor or co-mentors from Broad-, MIT-, or Harvard-affiliated faculty. The appointment is for one year, beginning on or after January 1, 2027, or another mutually agreed date, with the possibility of a second year based on satisfactory performance. Application review begins on a rolling basis after September 30, 2026. Visa sponsorship is offered.

Requirements

• Be within one year of an expected or completed Ph.D. in Computational Biology, Computer Science, Physics, Mathematics, Statistics, Biochemistry, Immunology, Chemical Biology, or Molecular Biology, or have strong knowledge of a variety of biological research areas.
• Strong analytical and written communication skills, including the ability to describe scientific material effectively to specialized and lay audiences.
• Ability to work effectively in an interdisciplinary environment.
• Commitment to participating in GaMBiT Initiative activities.
• Submit a CV, cover letter, research statement of up to three pages including references, and names and email addresses of at least three recommenders.

Responsibilities

• Conduct computational or experimental research advancing the GaMBiT Initiative’s mission to connect genetic discoveries with disease mechanisms, biomarkers, and therapeutic leads.
• Build large-scale analyses across siloed biobanks and integrate data across studies to create disease genome maps.
• Develop tools that enable experimentalists to access comprehensive genome information for diseases.
• Build AI agents to integrate and interpret genetic data using biological knowledge from literature.
• Develop scalable editing approaches for human cell types and profile proteins, regulatory elements, metabolites, and molecular interactions within single cells.
• Develop human genetics-derived cellular models and patient-tissue organoids for disease-specific perturbation studies.
• Participate in GaMBiT Initiative activities and work in an interdisciplinary research environment.

Benefits

• Medical insurance
• Dental insurance
• Vision insurance
• Life insurance
• Disability insurance
• 401(k) retirement plan
• Flexible spending and health savings accounts
• At least 13 paid holidays
• Winter closure
• Paid time off
• Parental and family care leave
• Employee assistance program
• Visa sponsorship

What This Job Offers

• Job Type: Full-time
• Career Level: Intern
• Education Level: Ph.D. or professional degree