Postdoctoral Associate, Pharmacology, Physiology & Biophysics, Chobanian & Avedisian School of Medicine
About The Position
The TCW laboratory in the Department of Pharmacology, Physiology & Biophysics at Boston University Chobanian & Avedisian School of Medicine is seeking motivated stem cell biologists or electrophysiologists to contribute to translating Alzheimer's Disease (AD) genetics into therapeutic interventions. The core program involves translating AD genetics and functional genomics into human brain cells using in vitro 2D and 3D models with human induced pluripotent stem cells (hiPSCs), including population and isogenic lines generated by CRISPR/Cas9 genome editing. The research will also utilize in vivo hiPSC/rodent chimera systems for comparison with post-mortem brain data. The focus will be on understanding the molecular mechanisms of major AD risk and protective variants, associated genes, and identifying targeted therapeutics. Additionally, research will explore human iPSC-glial transplantation in AD animal models, followed by in vivo electrophysiological and behavioral assessments to evaluate potential stem cell therapeutics. The successful candidate will collaborate within a multidisciplinary team of computational geneticists, neuroscientists, and pharmacologists at Boston University, including the Genome Science Institute and the Center for Systems Neuroscience.
Requirements
- Highly motivated and skilled stem cell biologist or electrophysiologist.
- Experience with human induced pluripotent stem cells (hiPSCs).
- Experience with CRISPR/Cas9 genome editing.
- Familiarity with in vitro 2D and 3D cell culture models.
- Experience with in vivo models (e.g., hiPSC/rodent chimera systems).
- Understanding of Alzheimer's Disease (AD) genetics and functional genomics.
- Ability to conduct molecular mechanism research.
- Experience with in vivo electrophysiology and behavioral readouts.
- Strong collaborative and multidisciplinary research skills.
Nice To Haves
- Experience with post-mortem brain analysis.
- Experience with glial transplantation in animal models.
Responsibilities
- Translate AD genetics and functional genomics into human brain cells using in vitro 2D and 3D models with human induced pluripotent stem cells (hiPSCs).
- Utilize in vivo hiPSC/rodent chimera systems for comparison with post-mortem brain data.
- Decipher the molecular mechanism of major AD risk variants, protective variants, and associated genes.
- Identify targeted therapeutics for AD.
- Conduct research on human iPSC-glial transplantation in AD animal models.
- Perform in vivo electrophysiological and behavioral readouts to evaluate potential stem cell therapeutics.
- Collaborate with a multidisciplinary research team including computational geneticists, neuroscientists, and pharmacologists.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
