Postdoc/Scientist - Psychiatry and Neuronal Health

Lilly • Indianapolis, IN

10d • $58,000 - $123,200 • Onsite

About The Position

The Psychiatry and Neuronal Health group at Eli Lilly is seeking a highly motivated Postdoctoral Research Fellow to join an active in vivo pharmacology program studying reward, arousal, and stress-related neural circuitry. The successful candidate will apply circuit-level tools, including fiber photometry, microdialysis, and behavioral pharmacology models, to characterize neuromodulatory signaling relevant to CNS drug discovery.

Requirements

• Ph.D. (or equivalent) in Neuroscience, Pharmacology, Behavioral Neuroscience, or a closely related field, completed within the last 1–3 years (or near completion)
• Hands-on experience with in vivo fiber photometry (calcium/neuropeptide sensor recording, signal processing, and analysis)
• Demonstrated expertise in rodent stereotaxic surgery, viral vector delivery, and fiber optic cannula implantation
• Experience with rodent operant/behavioral pharmacology models (IV self-administration, extinction, and/or cue reinstatement paradigms strongly preferred; IV catheterization experience a plus)
• Familiarity with in vivo microdialysis and downstream analytical quantification (HPLC/LC-MS or similar)
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization and visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1

Nice To Haves

• Working knowledge of reward, arousal, and/or stress-related neurocircuitry
• Proficiency in behavioral pharmacology and rodent handling (rat and/or mouse)
• Strong quantitative/analytical skills (MATLAB, Python, or R for photometry/behavioral data analysis)
• Track record of first-author publications in peer-reviewed journals
• Excellent written and verbal communication skills
• Experience with optogenetics and/or chemogenetics for circuit manipulation
• Experience with unbiased stereology
• Experience with multiplex fluorescence and in situ hybridization
• Experience with dual-site or multi-site simultaneous fiber photometry recording
• Experience with EEG/EMG sleep-wake scoring and vigilance state analysis
• Experience with genetically encoded biosensors

Responsibilities

• Design and execute in vivo experiments in rodent behavioral models relevant to CNS drug discovery, including chronic IV self-administration, extinction, and cue-induced reinstatement paradigms
• Perform rodent survival surgeries: stereotaxic viral injection, IV catheter implantation, and fiber optic cannula placement
• Perform single- and dual-site in vivo fiber photometry recordings (genetically encoded calcium and/or neuropeptide biosensors) to characterize real-time circuit dynamics during behavior, including during cue-triggered reinstatement testing
• Conduct in vivo microdialysis paired with LC/MS or immunoassay quantification to measure neurotransmitter/neuropeptide efflux across relevant brain nuclei
• Apply circuit-dissection techniques to map projections and test causal sufficiency/necessity in the behaviors under study
• Perform multiplex fluorescence and routine histological experiments
• Characterize sleep/arousal architecture (EEG/EMG) as relevant to project needs
• Support processing and molecular analysis of human postmortem brain tissue, including coordination with external tissue repositories
• Analyze and interpret multimodal datasets (behavioral, neurochemical, imaging, transcriptomic) using established computational pipelines
• Author manuscripts for peer-reviewed publication and present findings at internal reviews and external scientific conferences
• Maintain rigorous documentation, IACUC protocol compliance, and data integrity standards

Benefits

• A mentored postdoctoral appointment with a defined project, dedicated supervisor, and co-supervisor support
• Access to Lilly's internal drug discovery infrastructure, compound libraries, and cross-functional scientific expertise
• Strong publication support and encouragement to present at national/international conferences
• Competitive stipend and benefits per Lilly postdoctoral program guidelines
• Clear pathway for scientific development toward independent research or industry drug discovery careers
• company bonus (depending, in part, on company and individual performance)
• company-sponsored 401(k)
• pension
• vacation benefits
• medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree