Post Doctoral Fellow

Saint Louis University • St. Louis, MO

1d • Onsite

About The Position

NIH funded postdoctoral positions are available to study the structural enzymology of proteins responsible for blood coagulation (https://biochem.slu.edu/faculty/dicerawp/) with the goal of unraveling the molecular architecture and mechanism of the underlying interactions. The approach uses a combination of conventional (rapid kinetics, protein engineering, X-ray crystallography) and innovative (smFRET, cryo-EM) biophysical techniques. Current projects in the lab focus on the interaction of prothrombin with prothrombinase, leading to generation of thrombin and blood clotting, the activation of factor V required for assembly of prothrombinase and the interaction of the thrombin-thrombomodulin complex with protein C that halts the coagulation response. Additional studies focus on factor V short and its interactions with TFPIalpha, protein S and factor Xa and on proteins of the contact pathway like factors IX, XI and XII. The research associate (postdoctoral fellow) will work closely with a large research team (including SLU Education Policy faculty and graduate students, researchers in the SLU PRiME education policy research center, and SLPS administrative staff) to conduct research on Missouri education data, SLPS data, and continue their own research agenda.

Requirements

• Experience conducting program evaluations.
• Experience designing research projects related to education policy issues.

Nice To Haves

• Experience with conventional biophysical techniques (rapid kinetics, protein engineering, X-ray crystallography).
• Experience with innovative biophysical techniques (smFRET, cryo-EM).

Responsibilities

• Conduct research on Missouri education data, SLPS data, and continue their own research agenda.
• Study the structural enzymology of proteins responsible for blood coagulation.
• Unravel the molecular architecture and mechanism of underlying interactions.
• Focus on the interaction of prothrombin with prothrombinase, leading to generation of thrombin and blood clotting.
• Investigate the activation of factor V required for assembly of prothrombinase.
• Examine the interaction of the thrombin-thrombomodulin complex with protein C that halts the coagulation response.
• Conduct additional studies on factor V short and its interactions with TFPIalpha, protein S and factor Xa.
• Study proteins of the contact pathway like factors IX, XI and XII.

Benefits

• NIH funded postdoctoral positions

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: No Education Listed