Heersink School of Medicine - Pediatrics Neonatology - Post Doc

The University of Alabama at Birmingham Portal • Birmingham, AL

2d

About The Position

A postdoctoral scholar position in the Heersink School of Medicine’s Pediatrics Neonatology program is focused on mucosal immunology relevant to bronchopulmonary dysplasia (BPD) and chronic obstructive pulmonary disease (COPD). Funded by the National Institutes of Health (NIH), the American Heart Association (AHA), and UAB for at least three years, the position examines group 2 innate lymphoid cells (ILC2s) and the microbiome in chronic lung disease. The successful applicant will have the opportunity to develop multiple projects with direct translational impact using neonatal and adult mouse models in a well-equipped, multidisciplinary laboratory with strong collaborative opportunities.

The postdoctoral scholar will investigate preclinical development of trained immunity in ILC2s using integrated single-cell multiomic sequencing (RNAseq, ATACseq, and CUT & RUN), high-parameter spectral flow cytometry, microbiome analysis, bioenergetics, and in vitro culture of ILC2s isolated from human infants or derived from multiple transgenic mouse models. The scholar will design, interpret, and perform experiments addressing epigenetic and immunometabolic modulation of transcriptional pathways underlying trained immunity in ILC2s, and investigate their functional behavior and role in chronic lung disease in neonates and adults.

Requirements

• PhD

Responsibilities

• Develop research projects with direct translational impact using neonatal and adult mouse models.
• Investigate the preclinical development of trained immunity in ILC2s using single-cell multiomic sequencing, spectral flow cytometry, microbiome analysis, bioenergetics, and in vitro culture of ILC2s.
• Design, interpret, and perform experiments addressing epigenetic and immunometabolic modulation of transcriptional pathways underlying trained immunity in ILC2s.
• Investigate ILC2 functional behavior and their role in chronic lung disease in neonates and adults.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree