Post-Doc Research Associate

UNC-Chapel Hill • Chapel Hill, NC

1d

About The Position

Our collaborative and multidisciplinary translational tumor immunology group is seeking to hire a research associate who is highly skilled in cytometry and functional analysis of T cells to lead a project discovering tumor antigen-specific T cell receptors and mechanisms of resistance to antigen-specific T cell cytotoxicity in human cancer and tumor model systems. The goal of this research is to develop novel immunotherapies for this cancer which has a poor prognosis and very few if any good therapeutic options. The successful applicant will be able to conceive, plan, and execute experiments independently, as well as to analyze data and lead a small team in executing research goals in collaboration with principal investigators and other lab members. Beyond cytometry and functional T cell studies, experimental work will include single cell transcriptomic and T cell receptor analyses using human cell lines, primary tumor samples, and murine models. There will be substantial interaction with lab members working in bioinformatics and computational biology as well as opportunity for training in these areas if the applicant desires. As part of this work, they will be expected to lead and contribute to academic products including presentations, manuscripts, and patents deriving from their experimental results. If desired, the applicant will have the opportunity to be the lead author on presentations, manuscripts, and grants derived from their work.

Requirements

• PhD in immunology or similar discipline, or equivalent experience.
• Documented expertise in leading research projects through to completion.
• Demonstrated technical excellence in cytometry (flow cytometry and/or mass cytometry) including processing of samples for high-quality cytometry analysis.
• High-throughput functional analysis of T cell populations.
• Experience with murine immunotherapy treatment experiments.
• Capacity to independently analyze single cell multi-omics data (including T cell transcriptome + TCR data) in the context of immunotherapy response assessment.

Nice To Haves

• PhD in related field.

Responsibilities

• Lead a project discovering tumor antigen-specific T cell receptors and mechanisms of resistance to antigen-specific T cell cytotoxicity in human cancer and tumor model systems.
• Develop novel immunotherapies for cancer.
• Conceive, plan, and execute experiments independently.
• Analyze data and lead a small team in executing research goals in collaboration with principal investigators and other lab members.
• Perform single cell transcriptomic and T cell receptor analyses using human cell lines, primary tumor samples, and murine models.
• Lead and contribute to academic products including presentations, manuscripts, and patents deriving from experimental results.
• Have the opportunity to be the lead author on presentations, manuscripts, and grants derived from their work.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree