Post Doc - Open Rank - Wolfe Lab
About The Position
The Wolfe laboratory is seeking a postdoctoral researcher to develop therapeutic genome editing reagents for muscular dystrophies and cancer. This role involves developing prime editing reagents for precise correction of Limb Girdle Muscular Dystrophy mutations, creating genome editing reagents for cancer cell killing, using genome-wide techniques to assess off-target events, and translating these reagents to clinical applications through in vivo studies in mouse models. The position offers exposure to cutting-edge genome editor engineering, in vivo delivery via lipid nanoparticles, and deep-sequencing approaches for off-target editing evaluation. The candidate will also have opportunities to attend meetings and conferences in genome editing and gene therapy.
Requirements
- Ph.D. in biology, biochemistry, chemistry, or a related biomedical science.
- Strong oral and written communication skills.
- Eagerness to present research results at national meetings.
Nice To Haves
- Prior experience with genome editing systems.
- Prior experience with cell culture.
- Prior experience with deep-sequencing technologies.
- Prior experience with mouse disease models.
Responsibilities
- Develop prime editing reagents for precise correction of Limb Girdle Muscular Dystrophy mutations.
- Develop genome editing reagents for selective killing of cancer cells harboring gene amplifications.
- Utilize unbiased genome-wide techniques for assessing off-target events and other genomic alterations associated with genome editing.
- Translate developed genome editing reagents to clinical application through in vivo safety and efficacy studies in relevant mouse models.
- Learn cutting-edge deep-sequencing approaches to evaluate off-target editing within the genome.
- Participate in meetings/conferences associated with genome editing and gene therapy.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree
