Pharmacometrician & Systems Pharmacologist

Pfizer • New York City, MA

4d • Hybrid

About The Position

The Pharmacometrics & Systems Pharmacology (PSP) group is seeking a highly motivated quantitative scientist to support the Internal Medicine portfolio through the application of model-informed drug development (MIDD). This role will use pharmacometrics, systems pharmacology, and/or quantitative biology approaches to inform decision-making across drug discovery and clinical development. The successful candidate will contribute to the development and application of quantitative models to support and accelerate the discovery and development of novel therapeutics. This individual will work in multidisciplinary teams to design studies, interpret data, and guide strategy using mechanistic and/or data-driven modeling approaches. Candidates from diverse quantitative backgrounds, including pharmacometrics, systems pharmacology, applied mathematics, engineering, statistics, or related disciplines will be considered. This role will directly contribute to advancing innovative therapies in Internal Medicine by enabling data-driven, model-informed decisions that improve the efficiency, robustness, and success of drug development programs.

Requirements

• 0-3+ years post Ph.D. (or equivalent e.g. Pharm.D., or M.D.) in: Pharmacometrics, Pharmacokinetics/Pharmacodynamics, Systems Pharmacology, Applied Mathematics, Engineering, Physics, Statistics, Computational Biology, Mathematical Biology, or related quantitative discipline
• Demonstrated experience in quantitative modeling and simulation applied to biological or clinical systems
• Proven ability to work effectively in multidisciplinary teams
• Basic understanding and strong interest in biology and (patho)-physiology
• Strong written and verbal communication skills
• Candidates must be authorized to be employed in the U.S. by any employer. U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.
• This position requires permanent work authorization in the United States.

Nice To Haves

• Postdoctoral research experience strongly preferred
• Experience in metabolic diseases preferred (obesity, type 2 diabetes etc)
• Experience applying MIDD approaches in pharmaceutical or biotechnology settings
• Expertise in one or more of the following: NONMEM, Monolix, or similar population modeling tools
• Expertise in one or more of the following: R, Julia, MATLAB, Python, or equivalent computational platforms
• Knowledge of drug development processes (preclinical to clinical)

Responsibilities

• Develop and apply pharmacometric and/or mechanistic QSP models to support translational and clinical drug development
• Perform quantitative analyses including (as appropriate): Population PK/PD modeling, Exposure-response modeling (semi-mechanistic to empirical), Disease progression modeling, Model-based meta-analysis, Systems pharmacology / mechanistic modeling
• Integrate diverse data sources (preclinical, clinical, literature, biomarkers) for model development and validation
• Integrate artificial intelligence into data workflows and analytics
• Contribute to the development and execution of MIDD strategies across programs
• Inform key decisions including: Dose and regimen selection, Study design and optimization, Go/no-go decisions
• Identify opportunities where modeling can enhance understanding of efficacy, safety, and disease biology
• Partner closely with clinical pharmacology, statistics, clinical, translational, and biology teams
• Serve as a quantitative expert on multidisciplinary project teams
• Communicate modeling results and insights to technical and non-technical stakeholders
• Contribute to internal scientific strategy and methodological innovation
• Prepare high-quality technical reports, presentations, and regulatory documentation
• Author or contribute to scientific publications and external presentations
• Mentor junior scientists and contribute to best practices in quantitative pharmacology

Benefits

• 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
• Paid vacation, holiday and personal days
• Paid caregiver/parental and medical leave
• Health benefits to include medical, prescription drug, dental and vision coverage
• Relocation assistance may be available based on business needs and/or eligibility.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree