Imaging Science Lead Sr. Principal Scientist

Regeneron Pharmaceuticals • Boston, MA

11d • $150,500 - $245,500

About The Position

The Oncology Imaging Scientific Lead will lead the strategy and execution of complex early- and late-phase oncology imaging in clinical trials where imaging plays a critical role. Imaging includes all modalities, with a special focus on PET and CT. The role leads development of imaging biomarkers and supports the scientific imaging aspects and tumor response assessment of oncology clinical studies. The position is part of cross-functional program teams involving Regeneron clinical and preclinical colleagues and external academic and industry partners. It offers opportunities to develop innovative imaging biomarkers in support of clinical development and to help bring treatment options to patients.

The role may be based at one of the listed sites in Tarrytown, NY; Warren, NJ; Cambridge, MA; or Boston, MA. Remote work may be considered for the right candidate. Regeneron notes that many roles are expected to be performed on-site, with specific expectations to be discussed with the recruiter and hiring manager.

The position requires a doctorate in a relevant field and at least five years of industry and academic clinical oncology imaging experience. The salary range is $150,500 to $245,500 annually. The company describes a competitive total rewards package that may include annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits, paid time off, and family support benefits, depending on country and role.

Requirements

• Doctorate degree in a relevant field.
• At least 5 years of industry and academic clinical oncology imaging experience.
• Experience implementing central efficacy assessment using tumor response criteria such as RECIST 1.1, PCWG3, Lugano, and IMWG in oncology clinical trials.
• Leadership experience applying imaging as a quantitative endpoint in oncology-focused clinical and preclinical studies.
• Excellent written and verbal communication and organization skills.
• Ability to champion imaging innovations and lead projects effectively.

Nice To Haves

• At least 5 years of imaging experience in oncology drug development and clinical PET tracer development in a pharmaceutical or biotechnology setting.
• Experience applying imaging as a quantitative endpoint in clinical and preclinical studies.
• Experience with regulatory agencies and inspections.
• Direct experience with preclinical oncology imaging models using PET and immuno-PET imaging biomarkers.
• Strong background in oncology, biology, and molecular imaging, and familiarity with precision medicine approaches.
• Experience overseeing imaging CROs and implementing quality control procedures.

Responsibilities

• Work with imaging, therapeutic area, and development leads to formulate imaging biomarker strategies that inform and advance the clinical pipeline.
• Lead the design and implementation of multimodality imaging measures as endpoints for oncology therapeutic clinical studies.
• Collaborate with clinical teams as an imaging subject matter expert to optimize imaging strategy, including development of protocols, imaging manuals, imaging charters, and statistical analysis plans.
• Work with Clinical Imaging Operations and imaging CROs to ensure effective study conduct and data integrity for imaging components and endpoints.
• Serve as Imaging Scientific Lead in clinical trials focused on qualification and use of novel imaging biomarkers.
• Lead interactions with regulatory agencies and site ethics committees for approval of clinical imaging biomarker development studies.
• Design and implement novel PET, immuno-PET, and other novel imaging agents and biomarkers in clinical trials.
• Oversee image analysis and interpretation of results, and work with colleagues on study reports and publications as appropriate.
• Design and implement innovative imaging translational strategies with preclinical and clinical research teams and external partners.

Benefits

• Annual bonuses or other incentive plans may be offered, depending on country and role.
• Equity awards may be offered, depending on country and role.
• Pension or retirement benefits may be offered, depending on country and role.
• 401(k) company match may be offered, depending on country and role.
• Health and wellness programs may be offered, depending on country and role.
• Fitness centers may be available, depending on country and role.
• Insurance benefits may include medical, dental, vision, life, and disability insurance, depending on country and role.
• Paid time off may be offered, depending on country and role.
• Family support benefits may be offered, depending on country and role.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree