Neuroscience Research Associate / Research Specialist
About The Position
Altos Labs is seeking a highly skilled and meticulous Research Associate or Research Specialist (I/II) with exceptional expertise in in vivo brain surgeries and animal behavior to join the Rosi Lab within the Discovery Sciences organization at Altos Labs Bay Area. This role is pivotal in driving critical surgical workflows and generating disease-relevant models to uncover mechanisms of brain health and resilience, directly contributing to the company's mission of reversing disease and restoring cellular health. Altos Labs is recognized as a Top 3 Biotech Company and ranked on the Forbes 2026 Best Startups in America list, emphasizing a culture of collaboration, scientific excellence, and belonging.
Requirements
- Bachelor’s or Master’s degree in Neuroscience, Biology, Bioengineering, or a related scientific discipline.
- 5+ years of extensive, hands-on experience with stereotaxic and cranial window surgeries in rodent models within an academic or industry setting.
- Demonstrated success with intracranial viral vector (AAV) delivery and longitudinal in vivo study designs.
- Knowledge of neurodegenerative disease models (e.g., Alzheimer’s, tauopathies).
- Exceptional manual dexterity, high attention to detail, and the ability to work independently while collaborating effectively within a dynamic, fast-paced research team.
Nice To Haves
- Hands-on expertise with in vivo brain imaging with miniscope, awake head-fixed imaging paradigms, and behavioral habituation.
- Proficiency utilizing genetically encoded indicators, reporter lines, intravascular dyes, and neuronal tracers.
- Experience implanting complex devices like chronic cannulae, telemetry, and EEGs.
- Familiarity with advanced behavioral testing paradigms in rodents.
- Experience with tissue processing, sectioning, and immunohistochemistry downstream of surgical interventions.
Responsibilities
- Perform exceptionally precise cranial window surgeries in murine models, including preparation of chronic glass windows, headplate/headbar implantations, and setups optimized for longitudinal imaging.
- Execute highly accurate stereotaxic brain surgeries for targeted intracranial delivery of AAV vectors, anatomical/vascular tracers, and other therapeutic agents, adapting to strain-related anatomical variations.
- Independently manage the complete surgical workflow, encompassing sterile pre-operative preparation, precise anesthetic management, the surgical procedure, and meticulous post-operative monitoring and care.
- Work across a range of neurodegenerative models, strategically managing timed cohort generation to align with critical disease-stage endpoints.
- Conduct and support complex animal behavior assays in tandem with surgical models to correlate in vivo findings with functional outcomes.
- Maintain rigorous and detailed surgical records, ensure strict adherence to all IACUC protocols, and uphold the highest standard of animal welfare.
Benefits
- The salary range for Redwood City: Research Associate : $ Senior Research Associate : $ Research Specialist : $
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
