National Sales Director, Metabolics

Mirum Pharmaceuticals

1d•Remote

About The Position

Mirum Pharmaceuticals is a biopharmaceutical company dedicated to transforming the treatment of rare diseases. We are passionate about advancing scientific discoveries to become important medicines for rare disease patients. We are collaborative, creative, and experienced professionals and we’re looking to augment our team with other individuals who embody our values: care, be real, get it done, and have fun, seriously. The National Sales Director is a second-line field leader responsible for driving commercial performance, building high-performing Area Business Director (ABD) teams, and ensuring execution excellence across the Metabolics portfolio. This role translates national strategy into area and regional impact, with a strong emphasis on rare disease expertise, patient-centricity, and cross-functional leadership.

Requirements

Bachelor’s degree required
Minimum 7 years pharmaceutical/biotech experience
5+ years of leadership experience
Significant rare disease and/or specialty experience
Proven success in product launches, ideally with first-in-class therapies and in competitive markets
Demonstrated ability to build, lead, train and develop high-performing teams
Proven success in sales leadership roles with the ability to inspire, influence and align teams
Experience navigating complex rare disease patient journeys, including diagnosis, referral pathways, and difficult access to therapies
Strong leadership presence with the ability to inspire, influence, and align teams
Strong understanding of market access, payer dynamics, and patient services
Demonstrated ability to lead in a matrixed organization
High integrity, ethical standards, and commitment to compliance
Able to travel frequently, up to 60% overnight travel
Has a valid drivers’ license

Nice To Haves

MBA or advanced degree preferred
Successful experience leading leaders (second-line leadership) highly desired
Thrives in a fast-paced, dynamic, and collaborative environment

Responsibilities

Own and deliver national business performance across the Metabolics portfolio
Develop and execute product business plans aligned to national strategy
Analyze market trends, competitive dynamics, and performance data to inform actions
Lead, coach, and develop first-line leaders to maximize team effectiveness
Build a strong leadership pipeline and succession plans
Foster a culture of accountability, engagement, and continuous improvement
Ensure consistent and high-quality execution of brand strategy in the field
Monitor KPIs and drive disciplined performance management
Identify and scale best practices across regions
Partner with Marketing, Market Access, Medical Affairs, Patient Services and Operations
Ensure alignment of strategy and coordinated execution
Provide field insights to inform brand planning and lifecycle strategy
Maintain strategic relationships with key opinion leaders (KOLs) and top accounts
Understand regional nuances in referral patterns and treatment pathways
Support teams in navigating complex access and reimbursement environments
Ensure all activities comply with regulatory, legal, and company policies
Model integrity and patient-first decision making
Reinforce a culture of compliance across the organization