Snr RA, Pharmacology

Nosis Bio•Alameda, CA

11d•Onsite

About The Position

Nosis Bio is a well-funded biotech startup focused on cell-specific delivery of RNA therapeutics. The company combines expertise in receptor biology, generative AI, and high-throughput in vivo data generation to develop RNA therapeutics for new tissues, and partners with pharmaceutical companies, research institutions, and biotech companies. The Research Associate I / II / Senior Research Associate will conduct molecular biology-based assays to evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) properties of therapeutic candidates. This hands-on role supports drug discovery projects and involves high-throughput molecular biology assays, sample processing, mammalian cell culture, assay development, lab automation, data quality control, documentation, inventory management, equipment troubleshooting, and cross-functional coordination. The position is based onsite in Nosis Bio’s lab spaces at Research Park at Marina Village in Alameda, California. The level depends on academic and professional experience.

Requirements

Ability to work onsite in the company’s lab spaces at Research Park at Marina Village in Alameda, California.
Motivation, proactivity, and strong problem-solving skills.
Team-oriented approach and willingness to collaborate across scientific disciplines.
For Research Associate I: undergraduate degree and 0–2 years of industry or similar experience.
For Research Associate II: bachelor’s degree with 2–4 years of industry or similar experience, or master’s degree with 0–2 years of industry or similar experience.
For Senior Research Associate: bachelor’s degree with 4 or more years of industry or similar experience, or master’s degree with 2 or more years of industry or similar experience.

Responsibilities

Execute routine molecular biology workflows, including RNA/DNA extraction, cDNA synthesis, PCR/RT-qPCR, and ddPCR.
Prepare reagents, buffers, and master mixes, and maintain clean work practices using RNase-free technique.
Process samples from cells, tissues, and biofluids, including homogenization, lysis, cleanup, quantification, and normalization.
Maintain accurate, real-time documentation in the electronic lab notebook, including protocols, deviations, and raw data traceability.
Conduct data quality control and basic analysis, including standard curves, ddCt, and acceptance criteria, and summarize results for team review.
Support assay development and optimization, including primer/probe evaluation, thermal gradient optimization, input range testing, inhibition checks, and repeatability testing.
Maintain mammalian cell cultures, including immortalized, engineered, and primary cells, using aseptic technique; perform thawing, passaging, cryopreservation, cell counting and viability assessment, and routine mycoplasma testing; plate and prepare cells for downstream assays.
Use automated liquid handlers and other lab automation for plate-based assays; help develop, program, and validate instrument protocols, verifying accuracy and precision against manual methods.
Manage molecular and cell biology consumables inventory, coordinate ordering, monitor reagent lot changes, and qualify new lots as needed.
Troubleshoot core lab equipment, including qPCR/ddPCR instruments, plate readers, centrifuges, and biosafety cabinets, and escalate service needs appropriately.
Coordinate cross-functionally to ensure samples are collected, labeled, stored, and transferred correctly.
Share results across the company with clear context, controls, and interpretation.