(Senior) Manager, Supply Chain

nChroma Bio•Boston, MA

1d•$150,000 - $185,000

About The Position

nChroma Bio is a clinical-stage genetic medicines company developing engineered epigenetic silencers to overcome the limitations of existing therapies and enable next-generation genomic medicines. By combining in vivo delivery and gene-regulating technologies, nChroma is designing optimal solutions to deliver precise, potent and durable treatments for patients with high unmet needs. nChroma’s lead candidate, CRMA-1001, is a clinical-stage, liver-directed epigenetic silencer in development as a potential functional cure for chronic hepatitis B. Guided by a world-class team at the forefront of genetic medicine, founded by renowned pioneers in the field, and supported by top-tier investors, nChroma is redefining targeted in vivo genetic medicine with the initial goal of treating diseases affecting the liver, blood, cardiovascular and central nervous systems. We’re building a culture and organization to support this important mission, bringing together individuals that thrive in a supportive environment where diverse perspectives and a passion for discovery drive cutting-edge science and breakthrough medicines. ABOUT THE ROLE nChroma Bio is seeking a highly motivated Manager / Senior Manager, Clinical Supply Chain & Materials Planning to join our growing Supply Chain organization. This individual will play a critical role in supporting clinical supply operations across the CRMA-1001 program and future pipeline programs by overseeing clinical ancillary supply distribution, inventory management, and end-to-end supply planning for Drug Substance (DS), Drug Product (DP), and Finished Goods (FG). This role will partner closely with Technical Operations, Clinical Operations, CMC, Quality, Regulatory, external CMOs/CDMOs, depots, and logistics providers to ensure uninterrupted supply for global clinical studies. The ideal candidate will bring strong operational planning capabilities, clinical supply chain experience, and the ability to operate effectively in a fast-paced clinical-stage biotechnology environment.

Requirements

Bachelor’s degree in Supply Chain Management, Business Administration, Life Sciences, Engineering, or a related field with 5+ years of relevant experience within biotechnology or pharmaceutical industries.
Strong understanding of clinical supply chain operations, inventory management, and manufacturing planning within the biotechnology or pharmaceutical industry.
Experience supporting global clinical trials and distribution logistics for investigational products.
Strong analytical and problem-solving skills with the ability to proactively identify and mitigate supply risks.
Excellent organizational skills with the ability to manage multiple priorities simultaneously in a fast-paced environment.
Strong oral and written communication skills with the ability to effectively collaborate across cross-functional teams and external partners.
Ability to thrive in a dynamic and evolving clinical-stage biotechnology environment.
Collaborative, proactive, and resourceful mindset with strong attention to detail.
Passion for advancing innovative genetic medicines and improving patient outcomes.
Strong proficiency in Microsoft Office Suite, particularly Excel.

Nice To Haves

Experience managing external CMOs/CDMOs, depots, and logistics providers preferred.
Proficiency in GMP/GCP processes, labeling, and import/export requirements for clinical supplies.
Experience supporting GMP manufacturing and global clinical trial supply operations preferred.
Experience with inventory management and ERP systems preferred.

Responsibilities

Support global distribution of clinical ancillary supplies and investigational product (IP) to clinical trial sites and depots.
Coordinate shipments of Drug Substance, Drug Product, Finished Goods, and ancillary clinical materials domestically and internationally while maintaining chain of custody and temperature control requirements.
Develop and manage clinical site stocking strategies to support patient enrollment, dosing schedules, and study continuity.
Collaborate with Clinical Operations and depots to forecast site demand and minimize risk of stockouts or overstocking.
Coordinate import/export documentation and logistics activities to support global clinical trial operations.
Lead DS, DP, and FG batch planning activities in collaboration with CMC, Manufacturing, and Clinical teams.
Develop and maintain supply plans that account for manufacturing schedules, yield assumptions, clinical demand forecasts, safety stock requirements, and material expiries.
Maintain inventory tracking tools and systems that account for material production forecasts, supplier lead times, usage trends, stock levels, and expiry management.
Analyze inventory levels and manufacturing forecasts to identify supply risks, shortages, and mitigation strategies.
Process inventory reports from CMOs/CDMOs and ensure accurate reconciliation of materials across internal and external sites.
Support long-range clinical supply planning activities to ensure uninterrupted material availability for ongoing and planned studies.
Log material genealogy, production specifications, and inventory transactions within knowledge management systems and inventory databases.
Log materials received into inventory and maintain associated production and batch records.
Perform regularly scheduled audits of inventory systems and physical inventory to ensure accuracy and compliance.
Coordinate with shipping and receiving teams to ensure appropriate handling and placement of incoming materials.
Coordinate and track transfer of materials between internal teams, CMOs/CDMOs, testing laboratories, depots, and clinical sites.
Organize shipments for export and ensure compliance with applicable shipping regulations and documentation requirements.
Partner with CMC, Quality, Regulatory, Manufacturing, Clinical Operations, and Finance teams to support program execution and supply continuity.
Support technology transfer and manufacturing campaigns by ensuring timely availability of raw materials, consumables, and clinical components.
Create and communicate inventory and supply chain reports to senior management in a timely manner.
Develop project timelines and execution plans for supply chain initiatives and issue resolution activities.
Identify and evaluate alternative suppliers, materials, and supply strategies as necessary to mitigate operational risk.
Lead or support supplier management and supply chain improvement initiatives.
Support CMC cross-functional teams with approved inventory and material planning needs.
Assist with operational data entry, tracking, and documentation activities as needed.