Manager, Real World Evidence Science

CSL•Waltham, MA

2d•$134,000 - $159,000

About The Position

The Manager, Real World Evidence Science manages and provides technical expertise for Phase IV real-world evidence research across the influenza vaccine portfolio. The role supports studies on influenza epidemiology, vaccine effectiveness and safety, disease burden, vaccine use, and vaccine impact, and contributes to evidence-generation strategy, regulatory and medical responses, and internal decision-making. The position manages assigned studies from concept development through execution, analysis, and dissemination. It works with vendors, contract research organizations, database partners, academic collaborators, investigators, and internal teams to deliver rigorous research within timeline and budget expectations. The role also reviews and interprets real-world and meta-analytic data, supports scientific publications and presentations, monitors developments in research methods and standards, and ensures studies comply with applicable requirements and company policies. The expected base salary range at hiring is $134,000–$159,000. Total compensation may also include incentive compensation and equity. The stated salary range applies to the position in Massachusetts and may vary for an individual based on qualifications, skills, experience, competencies, and other relevant factors. The role may require up to 10% domestic and international travel.

Requirements

Graduate degree (Master’s or PhD) in public health, epidemiology, biostatistics, pharmacoepidemiology, health outcomes research, or a related scientific discipline; equivalent relevant experience may be considered.
At least three years of experience in observational research, real-world evidence generation, epidemiology, health outcomes research, or statistical programming using clinical, claims, registry, or electronic health record data.
Strong understanding of Phase IV outcomes research, observational study design, real-world evidence generation, and epidemiologic methods, including comparative effectiveness research, causal inference, confounding control, and vaccine effectiveness methods.
Experience using claims databases, electronic health records, registries, published literature, and other real-world data sources, and conducting systematic literature reviews and meta-analyses.
Experience programming and reviewing statistical analyses using SAS, SQL, R, Stata, or similar software.
Excellent oral and written communication skills, including the ability to translate complex scientific, epidemiologic, and statistical concepts into clear reports, presentations, publications, and internal evidence summaries.
Demonstrated project-management expertise, including the ability to independently manage multiple priorities, ambiguity, timelines, budgets, and quality expectations while exercising sound judgment.
Ability to establish productive working relationships, collaborate effectively, and build consensus with colleagues, managers, cross-functional teams, vendors, collaborators, and external experts in a global, highly matrixed environment.
Proficiency in Microsoft Word, Excel, and PowerPoint.
Ability to undertake up to 10% domestic and international travel.

Nice To Haves

R programming experience is preferred.
Experience in the biopharmaceutical industry, a contract research organization, an academic research setting, or a public health environment is preferred.
Experience in comparative effectiveness research, preferably in vaccinology, infectious diseases, influenza, or respiratory disease, is preferred.
A publication record in peer-reviewed clinical, epidemiologic, health outcomes, or methodological journals is preferred.

Responsibilities

Manage and provide technical expertise for Phase IV real-world evidence studies across the influenza vaccine portfolio, covering epidemiology, vaccine effectiveness, safety, disease burden, vaccine use, and vaccine impact.
Serve as project manager and technical project analyst for assigned internal- and external-facing studies; make scientific, methodological, and operational recommendations; contribute to evidence-generation strategy, regulatory and medical responses, and internal decision-making; and escalate matters with broader portfolio, strategic, or material resource implications.
Develop and review study concepts, protocols, statistical analysis plans, study reports, and internal evidence summaries.
Manage vendors, CROs, database partners, academic collaborators, and investigators; prioritize deliverables; develop contingency plans; and manage scientific, operational, methodological, timeline, data, and resource risks to deliver high-quality work within timeline and budget expectations.
Conduct systematic and targeted literature searches, qualitative evidence summaries, and meta-analyses to identify evidence gaps and support evidence-generation plans.
Review and interpret real-world and meta-analytic data and, where appropriate, conduct statistical analyses in accordance with approved research protocols.
Coordinate scientific dissemination through abstracts, congress presentations, manuscripts, and scientific exchange materials, including drafting and journal submission, author coordination, reviewer responses, data interpretation, presentation development, and scientific review.
Maintain knowledge of relevant literature, real-world evidence trends, epidemiologic methods, reporting standards, authorities, academic institutions, government entities, and emerging methodological approaches; identify opportunities to improve research processes and evidence generation.
Participate in CORE, Medical Affairs, and cross-functional project teams and collaborate with internal stakeholders, external experts, professional associations, vendors, and research partners.
Ensure studies and other company activities comply with applicable epidemiologic reporting and quality standards, including STROBE guidance, ClinicalTrials.gov registration requirements, Institutional Review Board requirements, applicable regulations, and company policies and procedures.