Manager Manufacturing, Purification - Nights

Amgen•West Greenwich, RI

5d•$106,148 - $143,612

About The Position

The Manager Manufacturing, Purification leads the night-shift purification manufacturing team at Amgen, championing a safe, compliant production environment through active on-floor leadership. The role oversees downstream processing operations and supports reliable, right-first-time production with a focus on patient safety, product quality, and compliance. It collaborates with Quality, EHSS, Facilities and Engineering, Process Development, and other site functions to troubleshoot issues and drive continuous improvement. With minimal direction, the manager leads manufacturing operations and staff, including supervision, hiring, onboarding, training, coaching, evaluation, and development. The manager helps define area objectives, identify improvement opportunities, lead change, and deliver short- and long-term manufacturing goals. The position supports reliability, efficiency, agility, and cross-training across AR5 and AR30. Onboarding lasts 2–6 weeks, during which the schedule is approximately Monday through Friday, 8 a.m. to 5 p.m. After onboarding, the role works D shift, 7 p.m. to 7 a.m., on a two-week rotation covering seven days per week. The schedule averages 14 shift days per month, includes every other weekend off, and provides a 15% shift differential.

Requirements

One of the following education and experience combinations: high school diploma or GED and 12 years of Manufacturing and Operations experience; associate’s degree and 10 years; bachelor’s degree and 5 years; master’s degree and 3 years; or a doctorate degree.
Experience directly managing people and/or leadership experience leading teams, projects, or programs, or directing resource allocation. This experience may run concurrently with the required technical experience.
Ability to lead manufacturing operations and staff and make timely decisions in a dynamic production environment.

Nice To Haves

Background in Life Sciences or Engineering.
Knowledge and experience in a cGMP or other highly regulated environment, including basic understanding of technical elements across engineering, biological, or chemical processing.
Experience in biologics purification or downstream manufacturing operations.
Skill in change management, team building, and fostering innovation.
Excellent communication skills, drive, sense of urgency, and analytical problem-solving abilities.
Demonstrated experience applying Operational Excellence and Lean Manufacturing.
Experience with performance management, including coaching, conflict resolution, and performance reviews.
Flexibility and ability to manage change.
Demonstrated ability to build and maintain strong relationships with other functional areas.
User-level fluency with digital tools for daily management, data analysis and visualization, and AI applications such as Copilot or ChatGPT.

Responsibilities

Champion and reinforce a strong safety and quality culture through active engagement and coaching; ensure purification activities follow approved procedures, batch records, and cGMP requirements.
Lead the shift and collaborate with peer managers to meet production targets; coordinate daily task allocation and plan short- to mid-term schedule needs with the scheduling team.
Maintain purposeful on-floor presence to monitor department performance, coach staff, and reinforce Floor Operating Principles.
Oversee purification operations, including activities such as chromatography, filtration, concentration, and buffer exchange, according to site procedures and process requirements.
Coordinate with support functions to troubleshoot, identify, and resolve on-shift issues.
Hire, onboard, train, evaluate, coach, and develop manufacturing staff; manage staff relations and performance while building a capable, engaged, high-performing team.
Define area objectives, identify improvement opportunities, lead change efforts, and deliver short- and long-term manufacturing goals.
Drive process improvements using operational data and staff input to improve efficiency, right-first-time performance, equipment reliability, and deviation prevention.
Plan and execute cross-training and dynamic resource allocation across AR5 and AR30 to improve responsiveness, productivity, and staff development.
Assist in developing and implementing departmental strategy and plans aligned with AR5, ARI, and site manufacturing objectives; translate priorities into daily, weekly, and shift-level plans.
Anticipate operational, quality, safety, training, equipment, and schedule risks and develop contingencies.
Use metrics, audit outcomes, process data, and staff feedback to identify trends and improve performance; lead changes that improve safety, compliance, quality, efficiency, throughput, and reliability.
Ensure staff understand how daily work connects to Amgen’s mission, patient impact, and business priorities.
Build effective cross-functional relationships and promote clear communication across shifts to support continuity, alignment, and readiness.
Foster accountability, innovation, continuous improvement, learning, knowledge-sharing, psychological safety, engagement, retention, and staff development.