Manager, Clinical Supply Chain

Rapport Therapeutics•Boston, MA

9d•$105,000 - $125,000•Hybrid

About The Position

Rapport Therapeutics is seeking a detail-oriented, execution-focused Manager, Clinical Supply Chain to support global supply chain operations for late-stage clinical development and commercialization readiness. As the company advances programs through Phase 3 and prepares for potential regulatory submissions, the role supports reliable, compliant, and scalable supply across global clinical trials. Reporting into Supply Chain leadership within CMC and Product Development, the manager supports day-to-day global clinical supply planning and execution, vendor coordination, and cross-functional alignment to help ensure uninterrupted supply of investigational materials. The position is based in Boston, Massachusetts, with an onsite requirement Monday through Wednesday each week. The role partners closely with CMC, Clinical Operations, Quality, Regulatory, and Program Management teams. It includes support for demand forecasting, inventory tracking, production scheduling, distribution coordination, external partner management, supply systems, IRT/RTSM implementation and lifecycle management, operational risk mitigation, and scalable process development.

Requirements

3–5 years of progressive experience in global supply chain or clinical supply chain management within the biopharmaceutical industry.
Bachelor's degree in Life Sciences, Engineering, Supply Chain, or a related field.
Experience supporting Phase 2/3 clinical trials.
Understanding of clinical development processes, GMP/GDP requirements, and global regulatory expectations for small molecule therapeutics.
Experience supporting external manufacturing, packaging, labeling, and logistics partners.
Strong attention to detail and ability to manage multiple operational priorities simultaneously.
Strong communication, problem-solving, and cross-functional collaboration skills.

Nice To Haves

Experience supporting commercial supply chain activities.
ASCM/APICS certification preferred, such as CSCP or CPIM.

Responsibilities

Support global clinical supply planning and execution for Phase 3 trials, including demand forecasting, inventory tracking, production scheduling, and distribution coordination.
Help ensure timely, compliant supply of drug substance, drug product, and clinical trial materials to global clinical sites on assigned programs.
Partner with CMC, Clinical Operations, Regulatory, Quality, and Program Management to align supply plans with manufacturing campaigns, clinical timelines, and regulatory milestones.
Support supply chain readiness activities for pivotal trials.
Support day-to-day relationships with CDMOs, packaging and labeling vendors, and logistics providers.
Assist with contract execution, performance monitoring, issue resolution, and continuous improvement initiatives across external partners.
Support clinical demand forecasting, inventory visibility, and supply reconciliation processes.
Use supply chain systems, planning tools, and dashboards to support data-driven decision-making and scenario planning.
Provide end-to-end support of IRT/RTSM implementation and lifecycle management, including URS development, system design and configuration, UAT, go-live readiness, drug supply and inventory transactions, and ongoing system changes.
Help identify supply chain risks related to capacity, lead times, regulatory requirements, or geopolitical factors, and support development of mitigation plans with leadership.
Contribute to the development and refinement of SOPs, KPIs, and scalable processes to support company growth.
Liaise with Clinical Operations teams on pharmacy manual development, site trainings, and other matters relating to drug supply handling and management at clinical sites.
Collaborate within supply chain initiatives and cross-functional project teams.
Contribute to a culture of accountability, innovation, and continuous improvement aligned with company values and growth objectives.