Manager, Clinical Supply Chain
About The Position
Centessa Pharmaceuticals, a clinical-stage company focused on developing orexin receptor 2 (OX2R) agonists for sleep-wake disorders, is seeking a Manager, Clinical Supply Chain. This role is responsible for the end-to-end planning, execution, and maintenance of uninterrupted clinical supply for assigned clinical programs. The position ensures GxP compliance, adherence to study timelines and budgets, and involves close collaboration with internal departments (Clinical Operations, CMC, Quality, Regulatory, Finance) and external vendors. The Manager will build relationships with internal teams and third-party suppliers, focusing on clinical forecasts, inventory systems, and IRT tools to support successful trial execution.
Requirements
- Bachelor's degree in engineering or science required.
- 3–5 years of biotech/pharma industry experience in clinical supply chain, including international experience, required.
- Working knowledge of clinical supply chain processes and GMP/GDP requirements.
- Experience coordinating cross-functional project teams and external vendors.
- Strong organizational, analytical, decision-making, and interpersonal skills, with excellent attention to detail.
- Ability to work independently in a fast-paced, dynamic environment.
- Demonstrated ability to coordinate CDMO activities supporting clinical development of pharmaceutical products.
- Ability to thrive in a small-company culture and contribute to creating and implementing processes.
Responsibilities
- Contribute to the development and execution of clinical supply strategies for early- to mid-phase clinical trials (Phase 1–3 as applicable).
- Manage clinical supply plans, demand forecasts, and inventory strategies — including tracking through Interactive Response Technology (IRT) systems — in alignment with protocol requirements and enrollment projections.
- Support packaging, labeling, distribution, and resupply activities for investigational products and comparators.
- Ensure on-time delivery of clinical supplies to depots and clinical sites globally.
- Partner with Quality, Clinical, CMC, and external CDMOs to develop, review, and approve clinical labels, and support CDMO packaging/labeling schedules to ensure supply availability.
- Interact regularly with third-party providers to manage the logistics and licenses required to ship materials from manufacturing to bulk storage facilities, courier depots, and investigator sites.
- Collaborate with CMC and QA to facilitate the document transfer required for IP/QP release by CDMOs.
- Monitor shelf-life and expiry dating, and coordinate retest/extension activities with the analytical team to ensure continuous supply.
- Manage the investigation, reporting, and communication of outcomes from temperature excursions and product complaints.
- Support product recovery activities pending investigation of IP from investigator sites, as needed.
- Communicate effectively across functional areas, applying a solid working knowledge of clinical supply chain processes.
- Author Pharmacy Manuals for clinical studies, as needed.
- Represent Supply Chain in Clinical and CMC Sub-Team meetings.
Benefits
- 401(k) plan
- company-sponsored medical, dental, vision, and life insurance
- generous paid time off
- health and wellness program
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Mid Level
