Machine Learning Engineer

BigHat Biosciences•San Mateo, CA

7d•$150,000 - $200,000•Onsite

About The Position

The role: We are seeking a creative, ambitious Machine Learning Scientist or Engineer to advance the state of the art in ML-driven therapeutic antibody design. At BigHat Biosciences our full-stack antibody drug development platform uses AI/ML to drive every stage from discovery to optimization. Our roboticized high-throughput wet-lab continually adds to our large proprietary datasets, which are piped through a custom LIMS++ data management and orchestration layer to automatically update and deploy the latest models. This makes development of complex, net-gen therapeutics ‘trivially parallelizable’, at a pace which only accelerates as we develop better ML tooling. You’re not interested in just git-cloning the latest NeurIPS pub and swapping out the dataset. Motivated by an enthusiasm for the possibility of addressing unmet patient need, and a curiosity about the underlying biology, you’ll apply your top-tier ML skillset to refine and expand this state of the art protein engineering platform. Success will mean not only hands-on methods development, but actively participating in the application of our platform to the accelerated design of new drugs for devastating diseases.

Requirements

Masters in ML/CS/EE or Bachelors with 3+ years industry experience; hands on experience developing and applying novel ML methods and a strong quantitative background.
Strong competency in Python, familiarity with PyTorch (even without LLMs!) and experience with modern software engineering best practices, including not just agentic/LLM-assisted coding but testing, CI/CD, etc.
Excellent communication skills, sufficient biomedical domain knowledge to interact effectively with diverse scientific teams.
Energy and ambition - ready to dive into a fast-paced environment and execute across multiple projects.

Nice To Haves

Familiarity with the current state-of-the-art in ML-driven protein engineering
experience with de novo design
NGS data
Bayesian optimization
familiarity with antibody biology and drug development
experience training and deploying models on AWS
publications at major ML conferences

Responsibilities

Design and implement the next state-of-the-art generative models of antibody sequence and structure, and predictive models of antibody properties, trained on proprietary internal datasets of thousands to millions of antibodies.
Develop multi-modality, multi-objective iterative protein sequence optimization approaches to lab-in-the-loop antibody design problems for validation and deployment in our high-throughput wet lab - at BigHat success is only declared upon synthesis of real antibodies with drug-like properties.
Develop, refine, and deploy agentic and LLM-driven optimization methods to further automate and accelerate our design-build-test loop.
Provide ML expertise and support for ongoing therapeutics programs, directly contributing to the development of new drugs.
Collaborate with our engineering team to ensure maximal efficiency in the automated deployment of our latest models and methods.
Work closely with an interdisciplinary team of drug developers, wet lab scientists, automation specialists, data scientists, etc. - every therapeutics program at BigHat is heavily interdisciplinary.