Lead Researcher - In Vivo & In Vitro Screening

St. Jude Children's Research Hospital•Memphis, TN

About The Position

We are seeking a motivated and detail-oriented Lead Researcher to investigate therapeutic approaches for pediatric cancers, with a focus on leukemia and medulloblastoma. Our research integrates cancer biology, molecular biology, functional genomics, and translational science. The successful candidate will lead and support in vitro and in vivo drug screening, including dose-response, combination therapy, and synergism studies, and use molecular and cellular approaches to define mechanisms of drug response. Projects will incorporate short and long-read RNA sequencing and other genomic approaches to generate mechanistic insights, with validation using molecular biology and cell-based assays. The ideal candidate will have hands-on experience in molecular and cell biology, including cell culture, flow cytometry, DNA/RNA isolation, western blotting and functional assays. Experience with drug screening, genomics, cancer models, or in vivo studies is highly desirable. This position offers an exciting opportunity to contribute to translational research aimed at developing improved therapies for children with cancer. This Position May be Ideal For: Master's level graduates with extensive laboratory experience looking to establish a track record of research productivity, including gaining high-position authorships on publications. Recent PhDs or research staff looking for an enriching, collaborative, and interdisciplinary lab environment committed to discovering new biology in the field of high-risk leukemia research.

Requirements

Bachelor’s degree in a relevant scientific area is required
5+ years of research experience is required
3+ years of experience is required with a Master’s degree
No prior experience required with a PHD
Strong knowledge and experience in understanding and application of underlying principles related to techniques being performed
Experience in R&D methods and processes in lab setting, and execution of research projects for the laboratory preferred
Proven performance in earlier role/comparable role
Hands-on experience in molecular and cell biology, including cell culture, flow cytometry, DNA/RNA isolation, western blotting and functional assays

Nice To Haves

Experience with drug screening, genomics, cancer models, or in vivo studies is highly desirable.

Responsibilities

Lead and perform in vitro and in vivo drug screening studies using established primary and patient-derived leukemia and medulloblastoma models
Design and execute dose-response, viability, combination, and drug-synergy studies
Develop, optimize, and troubleshoot cell-based and molecular assays
Utilize short- and long-read RNA-seq and other genomics approaches to investigate mechanisms of therapeutic response
Analyze and interpret experimental data, prioritize candidates to advance studies toward in vivo validation
Design and/or coordinate in vivo efficacy studies
Maintain comprehensive and well-organized experimental records