Lead Clinical Lab Scientist (3rd Shift, Tues-Sat)

Personalis•Fremont, CA

2d•Onsite

About The Position

Personalis is transforming the active management of cancer through personalized testing, using tumor-and-normal profiling and proprietary algorithms to provide insights as cancer evolves. Its products support early detection of minimal residual disease and recurrence, selection of targeted therapies through genomic profiling, and biomarker strategy for drug development. Personalis is based in Fremont, California. The Lead Clinical Lab Scientist performs and reports clinical laboratory testing that supports physicians in diagnosing and treating patients. The role helps supervise team members and ensures that laboratory procedures are followed for specimen handling, next-generation sequencing processes, test analyses, and accurate patient records. The lab offers hands-on work across multiple benches, including extractions, library preparation, and sequencing, and the position partners with lab assistants on pre-analytical and post-analytical tasks. The available schedule is Tuesday through Saturday, 10:00 p.m. to 6:30 a.m.; training hours may differ. Third-shift employees are eligible for an additional shift premium. The role may oversee or supervise laboratory activities in the absence of an onsite manager.

Requirements

Bachelor's degree, preferably in a science or related discipline.
Valid California Clinical Laboratory Scientist (CLS) or Clinical Genetic Molecular Biologist Scientist (CGMBS) license.
At least two years of CLS experience in a clinical laboratory environment.
Demonstrated leadership capabilities.

Nice To Haves

Four or more years of total work experience in a laboratory.
Experience with manual or automated library preparation.
Experience with manual or automated target enrichment.
Experience with automated liquid handlers.
Experience with Google Suite and Microsoft Excel.

Responsibilities

Perform and report clinical laboratory testing on patient samples to aid physicians in diagnosing and treating patients, including work in extractions, library preparation, and enrichments.
Handle and process patient specimens according to laboratory procedures, maintaining accurate and timely records and reporting results.
Execute LIMS data entry and review signoffs.
Select, implement, and evaluate quality control materials for statistical process control of laboratory assays.
Troubleshoot assays and equipment when quality control materials do not perform as expected.
Document corrective actions when test systems deviate from established performance specifications.
Work with Facilities to address building or facilities issues during the assigned shift and minimize disruption to processing.
Report incidents and non-conformances to the Quality team in coordination with OPS managers.
Assist with audits by regulatory bodies such as CAP and by external customers.
Participate in activities supporting laboratory licensure, including quality management and onsite inspections.
Maintain current knowledge of laboratory methods and how physicians use the resulting information through continuing education.
Identify and correct problems that may negatively affect test performance or result reporting; notify a supervisor, clinical consultant, or director if a problem cannot be corrected immediately.
Train other CLS and laboratory personnel on laboratory methods.
Monitor the activities of non-licensed staff.
Oversee or supervise laboratory activities as needed in the absence of an onsite manager.
Guide team members in troubleshooting and deviation investigations.
Assist with assay development activities.
Apply analytical skills, independent critical thinking, technical knowledge, and functional knowledge to help the team meet its goals.
Work independently to identify and resolve complex, open-ended problems.

Benefits

Annual performance-based bonus or sales incentive plan for full-time regular positions.
Long-term incentive units (equity) for full-time regular positions.
Medical benefits.
Dental insurance.
Vision insurance.
401(k) match.
Employee stock purchase plan (ESPP).
Tuition reimbursement.
Sick and vacation time.
Commuter benefits.
EV charging stations.
Onsite gym.
Wellness benefits.
Additional shift premium for the third shift.