Intern, Drug Product Development, CMC

Corner Therapeutics•Watertown, MA

2d•Onsite

About The Position

ai3Bio is developing immunotherapy platforms that aim to eliminate disease-causing Th17 cells and other inflammatory T cells in vivo. The Drug Product Development Intern will help advance multiple projects in a collaborative, fast-paced environment. The role offers opportunities to learn new skills and work with an interdisciplinary team of scientists to develop processes, formulations, and analytical assays for immunotherapy drug products. The position requires on-site work for at least 16 hours per week, with a minimum of four hours per day.

Requirements

Be a B.S. candidate in bioengineering, chemical engineering, chemistry, biochemistry, or an equivalent field.
Have hands-on laboratory experience in an academic or industry setting.
Have basic laboratory skills, including pipetting, weighing, using glassware, making solutions, and performing dilutions.

Nice To Haves

Experience with aseptic technique.
Experience with physicochemical characterization techniques such as HPLC, DLS, and pH measurement.

Responsibilities

Prepare formulations for drug delivery platforms, including mRNA-lipid nanoparticles, particulate suspensions, and polymer microparticles.
Characterize physicochemical properties of drug products using techniques such as HPLC, DLS, pH and osmolality measurements, microscopy, zeta potential, and plate-based absorbance assays.
Assist in developing benchtop and in vitro assays to define critical quality attributes of drug substances and drug products.
Collect, analyze, and organize data; troubleshoot; and communicate findings through written reports and team and company meeting presentations.
Proactively identify issues and develop solutions in a collaborative, multidisciplinary environment.
Maintain thorough and detailed electronic laboratory notebook and documentation records.