In Vivo Study Specialist

Parabilis Medicines•Cambridge, MA

3d•$75,000 - $85,000•Onsite

About The Position

Parabilis Medicines is seeking a highly motivated In Vivo Study Specialist to join their In Vivo Pharmacology team. This role will contribute to the preclinical evaluation of Helicon™ peptide therapeutics for oncology. It is a hands-on laboratory position focused on executing in vivo pharmacology studies in mouse oncology models and preparing high-quality ex vivo assays from tumor and normal tissue for downstream molecular and immune analysis. The successful candidate will be an integral member of a collaborative, multidisciplinary research team, working closely with Discovery Biology, Translational Sciences, DMPK, and external CRO partners. This role offers the opportunity to expand scientific expertise in oncology drug discovery while developing as a drug hunter through exposure to study design, data interpretation, translational pharmacology, and cross-functional research strategy. The ideal candidate will bring deep, hands-on in vivo technical skill, strong command of ex vivo tissue processing and assay preparation, and a passion for advancing innovative therapeutics.

Requirements

Extensive hands-on experience with mouse oncology models, including human xenograft, syngeneic, PDX, and genetically engineered mouse models.
Demonstrated mastery of advanced in vivo techniques: IV, IP, SC, and PO dosing; serial blood collection and PK sampling; tumor measurement; necropsy; and multi-tissue harvest.
Strong, hands-on experience with ex vivo tissue processing and assay preparation, histology sample prep, and molecular sample extraction (RNA/DNA/protein).
Experience with pharmacology, PK/PD, and efficacy study execution and analysis.
BS in Biology, Pharmacology, Cancer Biology, Immunology, or a related scientific discipline, or AALAS certification with equivalent relevant industry experience, and 3–5+ years of experience in biotechnology or pharmaceutical research.
Strong understanding of animal welfare regulations and experience supporting IACUC protocols.
Excellent organizational skills with the ability to manage multiple concurrent in vivo studies and ex vivo sample pipelines simultaneously.
Strong written and verbal communication skills and experience presenting scientific data.
Demonstrated ability to utilize AI tools for day-to-day work; baseline proficiency is expected, and advanced or innovative use of AI is a strong plus.

Nice To Haves

Experience performing minor and major rodent surgical procedures, including oncology-specific survival surgeries.
Familiarity with histology/IHC, and molecular biology techniques (qPCR, Western Blot, ELISA).
Exposure to translational pharmacology and oncology drug discovery programs.
Experience working in a fast-paced, cross-functional biotechnology environment.

Responsibilities

Independently execute in vivo pharmacology studies supporting target validation, lead optimization, mechanism-of-action, and efficacy evaluation of Helicon therapeutics.
Perform mouse oncology studies using xenograft, syngeneic, patient-derived xenograft (PDX), and genetically engineered mouse models (GEMMs).
Conduct routine and advanced in vivo procedures with a high standard of technical precision, including: Intravenous (IV), intraperitoneal (IP), subcutaneous (SC), and oral gavage (PO) dosing; Tumor cell implantation, caliper-based tumor measurement, and tumor growth monitoring; Serial blood collection and pharmacokinetic (PK) sampling via multiple routes; Body weight monitoring and clinical observations per IACUC-approved protocols; Terminal necropsy and systematic collection of tumor and tissue specimens for downstream analysis; Minor and major survival surgeries, including oncology-specific surgical procedures.
Execute PK/PD and efficacy studies evaluating tumor growth inhibition, pharmacodynamic biomarkers, drug exposure, and mechanism of action.
Own the ex vivo workflow from tissue harvest through assay-ready sample: dissection, fixation, freezing, and preservation of tumor and normal tissues for molecular and cellular analysis.
Prepare tissue for histology and IHC shipment.
Extract RNA/DNA/Protein and process plasma or tissue lysates for downstream Western Blot, qPCR, ELISA, or multiplex cytokine/biomarker profiling.
Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
Maintain detailed experimental documentation and contribute to study reports, presentations, and regulatory documentation.
Collaborate effectively across Discovery Biology, Medicinal Chemistry, DMPK, Translational Sciences, and Computational Biology teams.