Group Lead, Immunology

NewLimit•South San Francisco, CA
•$180,000 - $240,000

About The Position

NewLimit is a biotechnology company developing medicines to treat age-related diseases by reprogramming the epigenome and restoring regenerative potential in aged and diseased cells. Its work combines functional genomics, pooled perturbation screening, and machine learning to study epigenetic aging and disease. NewLimit seeks an immunologist with therapeutics leadership experience to lead its Immunology team. The team is developing reprogramming medicines intended to restore youthful function in aged T cells for inflammatory and infectious diseases, with an emphasis on T cell and regulatory T cell (Treg) biology. The role leads Scientists and Research Associates, develops assays and pre-clinical models, evaluates potential reprogramming payloads, and collaborates across technology and modeling teams. The Group Lead also contributes to company-wide product development and goals, while participating in day-to-day execution alongside the team.

Requirements

  • Ph.D. in cell biology, immunology, or a related field, or comparable industry experience.
  • Experience leading a team and managing direct reports.
  • Experience with therapeutics development, ideally leading part of a discovery or development process in an immunology, infectious disease, or inflammatory disease setting.
  • Deep knowledge of immunology and lymphocyte biology.

Nice To Haves

  • Direct experience with T cell biology, including relevant functional assays, pre-clinical models, and experimental methods.
  • Experience with in vivo nucleic acid delivery technologies.
  • Experience with pooled screening and related functional genomics methods.
  • Strong molecular biology foundations and experience designing transgenic constructs.
  • Experience with iterative product development cycles, such as design-build-test-learn.
  • Knowledge of aging biology, computational biology, and machine learning.

Responsibilities

  • Lead a team of Scientists and Research Associates developing reprogramming therapies.
  • Develop functional assays and pre-clinical models for inflammatory and infectious disease indications.
  • Evaluate reprogramming payloads with functional assays and pre-clinical models to validate payloads, select leads, and advance pre-clinical candidates.
  • Collaborate with Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test reprogramming interventions.
  • Contribute to product development decisions, company-wide goals, and the technology platform.
  • Contribute to day-to-day execution alongside the team.

Benefits

  • Health insurance
  • Dental insurance
  • Vision insurance
  • 401(k) with company match
  • Paid parental leave
  • 20 days of paid time off per year for all employees, plus holidays
  • Meals and snacks on-site
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