Gordian Apprenticeship

Gordian Biotechnology•South San Francisco, CA

13d

About The Position

Our apprenticeship offers a holistic experience in early-stage biotech, enabling you to refine practical laboratory skills while undertaking substantive, hands-on projects that will significantly expand your knowledge base. You'll play a pivotal role in assisting Gordian in identifying optimal therapeutic targets for new drug development. This opportunity grants you the chance to be at the forefront of rapid innovation, providing you with an insider's perspective into the dynamic landscape of a rapidly growing startup. As we progress further along the drug development pipeline, you’ll be actively involved in utilizing our platform to forecast preclinical and clinical physiological responses through our proprietary in vivo Mosaic screens. As a full-time team member you will collaborate closely with disease specialists, gene therapists, and our platform and data teams, gaining diverse experience within our collaborative matrix team environment. In this program, you’ll not only build crucial skills and experience as an early-career scientist, but also as a biotech professional, with insight into what it takes to build and grow a biotech company. You will learn about science, and the business of science, through company lunch and learns, monthly industry happy hours (hosted by Gordian), our exclusive speaker series, where you’ll hear from experienced industry/academic experts, and finally through 1:1 time with our founders. The year-long program will start in early June, and our ultimate goal is to give you an experience that will help inform the next steps in your career, whether that is at Gordian or providing you with connections and networking opportunities in both industry and academia that will set you up for whatever path you are passionate about pursuing. In addition, we offer competitive benefits with medical/dental/vision insurance, a 4% 401K employer match, free lunch 3x a week, and so much more!

Requirements

interest
intelligence
a willingness to work hard (alongside equally hard-working colleagues)
foundational knowledge of biology
organized and have a history of managing and collaborating on time-sensitive projects, working across multiple teams
excited to use cutting-edge technology to find the best therapeutic targets, and turn those into drugs
want to play a key role in an early-stage startup: A fast-paced environment full of both uncertainty and new challenges, demanding relentless resourcefulness, but full of opportunities and excitement
want a chance to do your best work, immerse yourself and excel, alongside people who will inspire you and whom you’ll be excited to spend your days with
can articulate how this apprenticeship supports your long-term development in the field

Nice To Haves

Prior lab experience is definitely a plus, especially the ability to follow protocols well and think critically about and understand what you’re doing
experience in areas that you are passionate or curious about: Enzymatic assays: Extracting protein/DNA/RNA from tissue samples, running assays like ELISA/spectrophotometry to measure protein and lipid levels.
Histology: Sectioning, staining, taking pictures and/or analyzing histological data. Bonus points for experience with mammalian tissues.
Mouse work: Colony maintenance, feeding, dosing oral treatments. Experience with blood draws, necropsies, and/or survival surgeries is a plus.
Plasmid cloning and production: standard DNA cloning techniques including PCR, gel electrophoresis, bacterial transformation, picking colonies, mini/midi-prep. Experience in plasmid design/maintenance on Benchling is a plus.
Sequencing: Creating and processing sequencing libraries. Experience with single-cell technologies or Illumina sequencers is a plus.
Tissue dissociation: Taking tissues from our in vivo screens and turning them into single-cell suspensions. Experience with animal sacrifices, fixation, and RNA quality control for RNA-seq are all pluses.
Flow cytometry: Ability to calibrate a cytometer, set gates to segregate cells from debris, and determine the percentage of fluorescent cells in a population. Experience with sorting and multiple fluorophores is a plus.
Large-scale genomic data analysis: Wrangling high-dimensional next-gen sequencing data specifically related to single cell RNA-sequencing (scRNA-seq) of disease and healthy tissues, and the associated workflows, tools and packages for performing appropriate quality control and statistical analyses of the same (e.g. using Scanpy, Seurat).
Data Communication & Cloud Infrastructure: Expert at distilling complex analysis into accessible visualizations for diverse audiences while leveraging AWS and Google Cloud (Linux environments) for seamless data storage and pipeline integration.
A grasp of start-up operations and dynamics: Operate in a culture where moving fast and taking calculated risks to drive science forward is the norm.
Entrepreneurship: Exhibit traits such as innovation, resilience, adaptability, and a willingness to challenge the status quo.