Global Asset Lead, Oncology Therapy Area, Research and Development

Orion Pharma • Boston, MA

17h • Hybrid

About The Position

Orion Pharma is seeking an experienced Global Asset Lead (GAL) to oversee the strategic vision and delivery of a priority oncology program. This role involves leading a Global Program Team (GPT) in a matrix environment, coordinating Clinical, Regulatory, CMC, Medical Affairs, and Commercial functions. The objective is to maximize the medical and commercial value of the asset from early development (Phase 1/2) through global registration, launch, and life cycle management. The position requires a blend of technical expertise (scientific and clinical) and business acumen (BD, portfolio strategy, market dynamics).

Requirements

• Advanced Degree: Ph.D. in Life Sciences, Pharm.D., or an equivalent doctoral-level degree (e.g., MD).
• Minimum of 15 years in pharmaceutical or biotechnology R&D.
• Minimum of 8 years specifically in Oncology Asset Leadership or a similar high-level matrix role.
• Documented success in leading a program through a global regulatory submission (NDA/BLA/MAA) and subsequent commercial launch.
• Proven ability to influence and lead large cross-functional teams without direct line-management authority in a Big Pharma environment.
• Experience managing large-scale program budgets.
• Sophisticated understanding of NPV/Asset Valuation models.
• Ability to transition between high-level strategic discussions and technical deep dives.
• Exceptional executive presence; ability to challenge senior leadership.
• Unwavering commitment to clinical data integrity and delivering meaningful outcomes to cancer patients.

Nice To Haves

• Experience in a dynamic matrix environment.
• Technical depth (scientific and clinical rigor).
• Business acumen (BD, portfolio strategy, and market dynamics).

Responsibilities

• Lead the creation and annual update of the Integrated Development Plan (IDP), ensuring alignment across clinical, regulatory, technical, and commercial workstreams.
• Develop, refine, and execute the Target Product Profile (TPP) to achieve a competitive and differentiated label.
• Partner with Medical Affairs and Clinical to drive an integrated evidence generation strategy (including RWE and HEOR) for market access and reimbursement.
• Lead the Global Program Team (GPT) as the central decision-maker, ensuring alignment on asset objectives.
• Serve as the primary liaison between technical R&D and downstream functions to ensure launch readiness.
• Proactively manage cross-functional priorities, trade-offs, and resource constraints.
• Act as the lead presenter for the asset at Senior Executive Governance meetings to secure funding and alignment.
• Establish clear 'Go/No-Go' decision points and present data for portfolio prioritization.
• Lead formal risk assessments and develop contingency plans for potential challenges.
• Strategize and execute on line extensions, including new indications, earlier lines of therapy, and combination regimens.
• Ensure the IDP includes global geographic considerations and pediatric investigation plans.
• Lead collaborations with academic groups and manage Joint Steering Committees for co-development assets.
• Serve as the asset expert for due diligence on in-licensing opportunities.
• Build and maintain relationships with Key Opinion Leaders (KOLs) and participate in strategic partnering discussions.
• Continuously monitor the oncology landscape to adjust asset strategy based on market dynamics and competitor activities.

Benefits

• Opportunities to work with talented and experienced scientists and assistants.
• An exciting R&D pipeline.
• Enthusiastic working environment.
• Opportunities to build competence and career.
• Opportunity to innovate and impact future therapies for patients.
• Wealth of career paths and development opportunities.
• Support for the development of innovative solutions and improving the quality of life.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree