Executive Vice President, Head of International

Mirum Pharmaceuticals•Foster City, CA

2d•Hybrid

About The Position

Mirum Pharmaceuticals is seeking an international biopharmaceutical executive to lead its business outside the United States through the company’s next phase of growth. Reporting to the President and Chief Operating Officer, the EVP, Head of International is accountable for international growth, commercial performance, launch execution, geographic expansion, and organizational development across direct markets, distributors, licensing partners, market access, and new market entry. The leader will scale Mirum’s established international business through multiple upcoming product launches while building capabilities across Asia Pacific and Latin America. They will create an operating model that empowers country leaders and maintains alignment across markets. The position calls for a senior commercial leader with broad international P&L leadership, rare disease or specialty-care commercialization experience, strong market access capabilities, and the ability to lead both direct affiliates and partner-led markets without overbuilding infrastructure.

Requirements

Bachelor’s degree required.
15+ years of progressive commercial leadership experience in the pharmaceutical or biotechnology industry, including substantial international responsibility.
Demonstrated regional or country general management experience with P&L accountability.
Experience leading multi-country organizations through matrixed operating models.
Demonstrated success launching and commercializing rare disease, specialty-care, or other high-value, low-prevalence products.
Experience with international pricing, reimbursement, market access, and launch sequencing.
Demonstrated experience evaluating geographic expansion and building new regional, affiliate, or commercial capabilities.
Broad understanding of international biopharmaceutical commercialization, including regional and country operating models, direct and partner-led go-to-market approaches, pricing, reimbursement, distribution, and compliance.
Strong strategic, financial, and operational leadership, connecting portfolio choices to regional execution and measurable business outcomes.
Ability to build lean, fit-for-purpose organizations.
Ability to assess market attractiveness, access feasibility, launch requirements, and direct-versus-partner economics across diverse geographies.
Executive presence and ability to influence senior leaders, program teams, and enterprise functions without relying solely on line authority.
Excellent judgment, communication, negotiation, and relationship-building skills across cultures and organizational levels.
Ability to lead through ambiguity, organizational change, growth, and competing priorities.
Demonstrated commitment to patient-centered decision making, ethical leadership, compliance, and Mirum’s core values.
Must be located in the San Francisco Bay Area or willing to relocate.

Nice To Haves

Advanced degree such as a master’s or doctorate degree.
Experience in both a large global organization and a smaller or emerging biotechnology environment.

Responsibilities

Own the international business plan, P&L, resource allocation, forecast, operating priorities, and performance-management process for worldwide markets outside the United States.
Translate enterprise and portfolio strategy into executable regional plans for Europe and Middle East, Canada, Latin America, and Asia Pacific.
Provide executive leadership with a clear view of international performance, opportunities, risks, and investment priorities.
Represent the international commercial perspective in enterprise portfolio, lifecycle, evidence, and business-development decisions.
Ensure disciplined execution of global price corridors.
Build a high-performing international leadership team and operating model.
Develop existing regional and country leaders and scale direct and distributor markets into a multi-product business across Europe, Canada, and Middle East.
Ensure launch readiness, market access, pricing and reimbursement, KOL development, commercial execution, and partner performance across the region.
Build and lead a regional leadership team for Asia Pacific and Latin America, establish fit-for-purpose strategies and operating models, and set performance expectations.
Develop market-prioritization frameworks considering patient need, regulatory feasibility, access potential, pricing implications, operational complexity, and commercial return.
Recommend commercial models for priority markets, including partner-led, direct, and licensing approaches.
Lead ex-US launch readiness across the portfolio, including access, pricing, evidence generation, supply readiness, and launch sequencing.
Ensure development and commercialization strategies incorporate international market requirements, and establish repeatable launch-excellence processes.
Assess business-development opportunities and potential products through an international commercial and access lens.
Drive post-launch performance and sharing of best practices across markets.
Establish performance expectations, decision rights, escalation processes, and KPIs for distributors and license partners.
Drive partner performance across registration, access, commercialization, and supply, and build accountable partnerships that advance strategic and financial objectives.
Develop fact-based direct-versus-partner recommendations for priority markets and present investment cases to executive leadership.
Oversee international pricing architecture and price-corridor execution, including international reference-pricing considerations in launch sequencing and contracting decisions.
Align regional access strategies with global evidence priorities, product value narratives, and local reimbursement requirements.
Establish disciplined forecasting, analytics, and business-planning processes.
Ensure international market needs are reflected in product, lifecycle, and evidence-generation planning.
Lead, coach, and develop a geographically dispersed, multicultural leadership team with clear accountability for business outcomes.
Partner with US Commercial, Medical Affairs, Clinical Development, Regulatory, Finance, Legal, Compliance, CMC, Supply Chain, Quality, Safety, Patient Advocacy, and program teams.
Influence enterprise decisions through strategic clarity, operational credibility, and cross-functional relationships.
Build scalable capabilities, processes, succession depth, and leadership capacity appropriate for a growing rare disease company.
Represent Mirum with external partners, government and reimbursement stakeholders, patient communities, and other senior external audiences, as appropriate.