Executive Director, Supply Chain & External Manufacturing

Prime Medicine•Cambridge, MA

3d•$295,000 - $312,000

About The Position

Prime Medicine is a clinical-stage biotechnology company developing gene-editing therapies using its proprietary Prime Editing platform. The Executive Director of Supply Chain and External Manufacturing reports directly to the Chief Technology Officer and is a member of the Technology, Development and Operations (TDO) leadership team. This leader owns the end-to-end supply chain, from raw materials through clinical supply and commercialization, with direct accountability for materials management and support of internal planning and manufacturing needs. The role manages external manufacturing partners, leads a lean team, and partners with Finance on TDO external spend. It also leads the application of AI and digital tools across supply chain and external manufacturing. The position is based in Cambridge, Massachusetts. The role calls for a leader who is comfortable with ambiguity, energized by building, and able to combine strategic thinking with hands-on execution. The position is eligible for annual short-term and long-term incentive awards. Prime Medicine offers a comprehensive benefits package, including health, financial, and wellness benefits, paid time off, wellness days, and company-wide recharge breaks.

Requirements

Bachelor’s degree in a relevant technical discipline.
15–20+ years of progressive experience in supply chain, technical operations, external manufacturing, process development, or MSAT within biotech or pharma.
Direct ownership of materials management and clinical supply for clinical-stage programs.
Experience managing CDMOs and CROs, including negotiating MSAs and SOWs.
Financial acumen, including ownership of operating budgets and multi-year cost projections.
Strong change management, project management, and communication skills, with the ability to build trust with partners, Finance, and senior leadership.

Nice To Haves

Advanced degree (MS, MBA, or PhD).
Experience with cell therapy and/or LNP or nucleic acid programs.
Experience supporting IND/CTA and BLA/MAA submissions.
Track record of implementing AI or digital tools that improved supply chain or operations forecasting, visibility, or decision-making, and changing team practices as a result.
Experience in a lean, fast-moving biotech environment.
Experience with ultra-rare diseases or small patient populations.

Responsibilities

Partner with the CTO and TDO leadership to define manufacturing and supply chain strategy, including network design, make-versus-buy decisions, and partner selection.
Lead the use of AI and digital tools for demand forecasting, materials and inventory visibility, partner performance monitoring, contract and cost modeling, and logistics tracking; assess emerging tools.
Own materials management across the portfolio, including forecasting, sourcing, purchasing, and inventory of raw materials, critical starting materials, and components.
Support internal planning and program manufacturing needs; ensure timely labeling, packaging, shipping, and cell therapy logistics, and resolve supply risks before they affect timelines.
Build and manage a network of CDMOs, CROs, and critical suppliers, including contracts, governance, performance, and qualification of new partners.
Ensure supply chain documentation and external site readiness support IND and BLA submissions, working with CMC, Regulatory, Quality, Non-clinical Development, Clinical, and program teams.
Own TDO budget development for external spend, cost projections, and financial reporting in partnership with functional leaders and Finance.
Lead, coach, and inspire supply chain and external manufacturing professionals and indirect colleagues across TDO; foster accountability, continuous improvement, collaborative problem-solving, and goal attainment.