Engineer II, Process safety

Takeda•Boston, MA

1d•$71,800 - $112,860•Onsite

About The Position

Join Takeda as an Engineer II, Process Safety. As part of the SMPD - Process Engineering & Technology team, you will report to the Associate Director of Process Engineering. As the Engineer II, Process Safety you will take charge of cutting-edge process safety workflows and evaluations, ensuring that the latest technologies are leveraged at every stage of process research, development, and manufacturing. They will be responsible for reducing process risks and enabling a safer, smarter, and faster development Additionally, the Engineer II will help build and maintain SMPD’s process safety database while championing an in-silico first mindset to minimize experimentation and promote data-driven decisions. At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide. The Process Development, Engineer II is responsible for performing engineering operations within the organization, focusing on designing, constructing, testing, and operating equipment. This role ensures standards of quality, cost, safety, reliability, timeliness, and performance are met in production processes, contributing to Takeda's mission of bringing better health to people and a brighter future to the world.

Requirements

Associates degree in chemistry, biology, pharmacy, engineering or related pharmaceutical science and 2+ years relevant industry experience
Bachelors degree in chemistry, biology, pharmacy, engineering or related pharmaceutical science; some relevant industry experience preferred
Previous experience working in a lab setting preferred.
Previous experience working in a pilot plant setting a plus.
Previous experience in process safety in the pharmaceutical, agrochemical, fine chemical or related industry a plus.
Experience using relevant process safety equipment (e.g. DSC, RC1, Easymax HFCal, ARC, Tsu) a plus.
Previous experience with software packages for process safety prediction (e.g., AKTS, Aspen Plus, gPROMS) a plus, focusing on the prediction of thermal, chemical, and kinetic properties.
Understanding of FAIR data principles (Findable, Accessible, Interoperable, Reusable) to drive efficient data management for safety modeling and analytics.

Responsibilities

Support phase appropriate process safety testing.
Work with process chemists and engineers to perform a thorough evaluation of all known and potential hazards for the safe scale-up of chemical processes for preparing pharmaceutical intermediates and active pharmaceutical ingredients in Takeda's research and manufacturing facilities.
Collect and integrate relevant process safety data (e.g., calorimetry, pressure build-up, off-gassing), using for e.g. DSC, ARC, TSU, EasyMax, RC-1 and ARC into digital platforms for seamless data analysis and sharing, ensuring data complies with FAIR principles (Findable, Accessible, Interoperable, Reusable).
Work with external vendors to collect relevant process safety data.
Document and summarize safety results in an Electronic Lab Notebook (ELN) and generate comprehensive digital process safety reports, ensuring consistent and accessible data tracking and compliance documentation.
Partner with internal & external manufacturing organizations to ensure the safe scale-up of Takeda's processes.
Use software and build models to calculate critical process parameters, such as runaway reactions, self-accelerating decomposition temperature (SADT), and time to maximum rate under adiabatic conditions (TMRad), driving proactive safety interventions.
Maintain SMPD's kilo labs, ensuring that they are safe, clean and functional.
Manage the kilo lab inventory (including chemicals, reagents, equipment & consumables) and ensure adequate supplies are available.
Coordinate with contractors, vendors, and internal stakeholders to oversee the installation, commissioning, and qualification of kilo lab equipment and systems.
Oversee internal manufacturing campaigns (e.g. reviews batch records, set-up equipment, support execution & cleaning).
Support local initiatives as directed by his/her supervisor and participate in global functional initiatives as appropriate.