Downstream Process Development, Engineer II

Takeda•Lexington, MA

7d•$71,800 - $112,860•Onsite

About The Position

As an early-career professional, this role supports downstream biotherapeutics process development through hands-on purification and recovery development experiments. The individual contributor role supports process development across multiple scales, from micro scale through bench and pilot scale, and contributes to both early-stage and late-stage programs. The role involves working in teams with more senior process engineers to collaboratively execute larger experiments, while also working closely with process development team members to generate data, maintain accurate records, and contribute to the development and optimization of downstream processes.

Requirements

Associate degree with 2+ years of relevant experience, or bachelor’s degree with relevant experience, in chemical engineering, chemistry, biochemistry, biotechnology, or a related field.
Experience with chromatography, harvest, ultrafiltration and diafiltration, and viral clearance steps.
Comfort with emerging digital tools and openness to AI-enabled processes that support data analysis, documentation, and workflow improvement.
Experience with basic bioprocess control systems.
Experience using electronic laboratory notebooks for study documentation/data entry.
Ability to perform basic data analysis and present results clearly in written form.
Familiarity with technical writing for laboratory reports or development documents.
Understanding of laboratory practices, process development methods, and quality requirements.
Ability to follow detailed procedures, maintain accurate records, and work under close supervision.
Some relevant experience in process development, protein purification, or a related laboratory setting.

Responsibilities

Execute chromatography, harvest operations, ultrafiltration and diafiltration (UF/DF), and viral clearance experiments with additional potential support of bioconjugation.
Support downstream process development across micro scale, bench scale, and pilot scale studies.
Help maintain laboratory equipment and support routine readiness of instruments used in process development work.
Work with more senior process engineers to collaboratively plan and execute larger experiments and study activities.
Document experimental work in electronic laboratory notebooks and maintain clear, complete, and timely records.
Perform basic data analysis to review trends, compare conditions, and support study conclusions.
Prepare technical summaries, study updates, and other written materials to share results and findings.
Follow established laboratory and process development procedures, including quality and safety requirements.
Contribute to continuous improvement efforts by identifying ways to improve workflows, data capture, and experimental execution.
Assist with small projects or specific project tasks under close supervision.