Downstream Process Development, Engineer II

Takeda•Lexington, MA

5d•Onsite

About The Position

As an early-career professional, you handle problems of limited scope and complexity, adhering to established policies and procedures. Your decision-making is within a defined scope, using standardized methods to analyze situations and data. You are developing knowledge of basic principles, theories, and concepts, and beginning to apply industry practices and standards. Typically, this role requires some relevant experience, with contributions mostly related to task-specific activities. Your primary contacts are with your immediate team, and you work under moderate direction and close supervision, following specific, detailed instructions. The Downstream Process Development, Engineer II is responsible for supporting downstream biotherapeutics process development through hands-on purification and recovery development experiments. This individual contributor role supports process development across multiple scales, from micro scale through bench and pilot scale, and contributes to both early-stage and late-stage programs. You will work in teams with more senior process engineers to collaboratively execute larger experiments, while also working closely with process development team members to generate data, maintain accurate records, and contribute to the development and optimization of downstream processes.

Requirements

Associate degree with 2+ years of relevant experience, or bachelor’s degree with relevant experience, in chemical engineering, chemistry, biochemistry, biotechnology, or a related field
Experience with chromatography, harvest, ultrafiltration and diafiltration, and viral clearance steps
Comfort with emerging digital tools and openness to AI-enabled processes that support data analysis, documentation, and workflow improvement.
Experience with basic bioprocess control systems
Experience using electronic laboratory notebooks for study documentation/data entry
Ability to perform basic data analysis and present results clearly in written form
Familiarity with technical writing for laboratory reports or development documents
Understanding of laboratory practices, process development methods, and quality requirements
Ability to follow detailed procedures, maintain accurate records, and work under close supervision
Some relevant experience in process development, protein purification, or a related laboratory setting

Responsibilities

Execute chromatography, harvest operations, ultrafiltration and diafiltration (UF/DF), and viral clearance experiments with additional potential support of bioconjugation.
Support downstream process development across micro scale, bench scale, and pilot scale studies
Help maintain laboratory equipment and support routine readiness of instruments used in process development work
Work with more senior process engineers to collaboratively plan and execute larger experiments and study activities
Document experimental work in electronic laboratory notebooks and maintain clear, complete, and timely records
Perform basic data analysis to review trends, compare conditions, and support study conclusions
Prepare technical summaries, study updates, and other written materials to share results and findings
Follow established laboratory and process development procedures, including quality and safety requirements
Contribute to continuous improvement efforts by identifying ways to improve workflows, data capture, and experimental execution
Assist with small projects or specific project tasks under close supervision